Heat shockin vivo modulates cytotoxicity of xenobiotics |
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| Authors: | A B Egorova T A Romanova V V Ivanov V P Nefedov |
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| Institution: | (1) Krasnoyarsk State Medical Academy, Siberian Division of the Russian Academy of Sciences, Siberian, USSR;(2) Krashoyarsk State Agrouniversity, Siberian Division of the Russian Academy of Sciences, Siberian, USSR;(3) Krasnoyarsk Research Center, Siberian Division of the Russian Academy of Sciences, Siberian, USSR |
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| Abstract: | Heat shock was modeledin vivo for induction of cross-thermotolerance to acrylamide, a xenobiotic inductor of oxidative stress. Single hyperthermia (40–41°C,
25 min) reduced neuro- and hepatotoxicity of xenobiotic toxifying by phenobarbital-, but not methylcholanthrene-induced cytochrome
P-450 isoforms (the hexenal test).
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 546–547, November, 1998 |
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| Keywords: | heat shock xenobiotics cytochrome P-450 |
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