| 大鼠脑缺血再灌注后海马CA1区星形胶质细胞与突触可塑性的关系 |
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| 引用本文： | 郭涛,王新华,石磊,陈宁宁,赵源征,张敏,刘恒方.大鼠脑缺血再灌注后海马CA1区星形胶质细胞与突触可塑性的关系[J].中国实用神经疾病杂志,2012,15(11):23-25. |
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| 作者姓名： | 郭涛 王新华 石磊 陈宁宁 赵源征 张敏 刘恒方 |
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| 作者单位： | 郑州大学第五附属医院神经内科,郑州,450052 |
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| 摘 要： | 目的 研究大鼠脑组织缺血再灌注后星形胶质细胞与GAP-43变化的关系.方法 建立局灶性脑缺血再灌注模型.72只大鼠随机分为假手术组、缺血再灌注组,在各时间点处死取脑,应用免疫组化法检测海马CA1区GFAP、GAP-43的表达.结果 不同时间点缺血再灌注组GFAP、GAP-43表达均高于同时期假手术组(P＜0.01);缺血再灌注组GFAP与GAP-43高度相关(P＜0.05).结论 脑缺血再灌注后,海马CA1区星形胶质细胞与GAP-43变化具有高度相关性.
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| 关 键 词： | 脑缺血再灌注 星形胶质细胞 神经生长相关蛋白 相关性 |
A correlation study on astrocyte and synaptic plasticity in hippocampus CA1 of rats after ischemia-reperfusion |
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| Guo Tao
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Wang Xinhua
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Shi Lei
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Chen Ningning
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Zhao Yuanzheng
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Zhang Min
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Liu Hengfang.A correlation study on astrocyte and synaptic plasticity in hippocampus CA1 of rats after ischemia-reperfusion[J].Chinese Journal of Practical Neruous Diseases,2012,15(11):23-25. |
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| Authors: | Guo Tao Wang Xinhua Shi Lei Chen Ningning Zhao Yuanzheng Zhang Min Liu Hengfang |
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| Institution: | .Department of Neurology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
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| Abstract: | Objective To study the correlation between astrocyte and GAP-43 in hippocampus CA1 of rats after ischemia-reperfusion.Methods The model of focal cerebral ischemia-reperfusion was made.Total 72SD rats were randomly divided into the sham-operated group and ischemia-reperfusion control group.The rats were killed at different time points,the brains were taken out and fixed.Immunohistochemistry was used to detect the expressions of GFAP and GAP-43in hippocampus CA1.Results The expressions of GFAP and GAP-43in the ischemia-reperfusion control group were significantly higher than those in the sham-operated group at the same time points(P<0.01).GFAP was correlated with GAP-43(P<0.05).Conclusion Astrocyte and GAP-43in hippocampus CA1have high correlation after ischemia-reperfusion. |
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| Keywords: | Cerebral ischemia-reperfusion Astrocyte GAP-43 Correlation |
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