| 电离辐射对小鼠胸腺中多巴胺β羟化酶及β_2受体mRNA表达的影响 |
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| 引用本文： | 刘林林,田梅,傅海清,鞠桂芝,尉军. 电离辐射对小鼠胸腺中多巴胺β羟化酶及β_2受体mRNA表达的影响[J]. 吉林大学学报(医学版), 2003, 29(2): 128-130 |
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| 作者姓名： | 刘林林 田梅 傅海清 鞠桂芝 尉军 |
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| 作者单位： | 1. 吉林大学第二医院放疗科,吉林,长春,130021
2. 卫生部放射生物学重点实验室 |
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| 基金项目： | 教育部留学回国人员科研启动基金;; |
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| 摘 要： | 目的 :探讨交感神经系统调节辐射所致免疫功能变化的分子机制。方法 :采用斑点印迹杂交检测 X射线全身照射后小鼠胸腺中 DβH m RNA及 β2 - ARm RNA表达的变化。结果 :无论75 m Gy还是 2 Gy X射线全身照射后 8、48和 72 h,小鼠胸腺中 DβH m RNA表达较对照组升高约5 0 %～ 60 % ,β2 - AR m RNA表达较对照组也有升高趋势。结论 :X射线全身照射可诱导 DβHm RNA及β2 - AR m RNA的表达 ,提示交感神经系统是通过直接和间接两种方式对免疫系统进行调节 ,并在辐射生物效应中起到不可忽视的调节作用。
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| 关 键 词： | 辐射,电离 多巴胺β羟化酶 受体,多巴胺 交感神经系统 |
| 文章编号： | 1671-Ⅹ587(2003)02-0128-03 |
| 修稿时间： | 2002-03-09 |
Effect of Ionizing Radiation on DβH mRNA and β2-AR mRNA Expressions in Thymus in Mice |
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| LIU Lin lin ,TIAN Mei ,FU Hai qing ,JU Gui zhi ,WEI Jun. Effect of Ionizing Radiation on DβH mRNA and β2-AR mRNA Expressions in Thymus in Mice[J]. Journal of Jilin University: Med Ed, 2003, 29(2): 128-130 |
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| Authors: | LIU Lin lin TIAN Mei FU Hai qing JU Gui zhi WEI Jun |
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| Affiliation: | LIU Lin lin 1,TIAN Mei 2,FU Hai qing 2,JU Gui zhi 2,WEI Jun 2 |
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| Abstract: | Objective: To explore the molecular mechanism of regulation of sympathetic nervous system in the changes of immunization induced by radiation. Methods: Dot blot was used to analyze DβH mRNA and β 2 AR mRNA expressions in thymus in mice after whole body irradiation. Results: The expressions of DβH mRNA in thymus in mice increased greatly after 75 mGy and 2Gy whole body irradiation. The expressions of β 2 AR mRNA in thymus in mice has a increasing tendency after 75 mGy and 2 Gy whole body irradiation. Conclusion: These suggested that sympathetic nervous system may play an important regulatory role in the irradiation effect. |
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| Keywords: | Radiation ionizing Dopamine beta hydroxylase Receptors dopamine Sympathetic nervous system |
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