| 视网膜色素变性治疗的研究进展 |
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| 引用本文： | 周朋义,彭广华.视网膜色素变性治疗的研究进展[J].眼科新进展,2012,32(5):493-496. |
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| 作者姓名： | 周朋义 彭广华 |
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| 作者单位： | 郑州大学第一附属医院眼科,河南省郑州市,450052 |
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| 基金项目： | 国家自然科学基金资助(编号:81150034);2011年度郑州大学第一附属医院创新科研团队建设基金~~ |
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| 摘 要： | 视网膜色素变性(retinitis pigmentosa,RP)是由视网膜光感受器和视网膜色素上皮变性所引起的致盲性、遗传性眼病,目前尚无有效的治疗方法,相关治疗研究还处于探索阶段,如基因治疗、药物治疗、移植治疗、人工视网膜假体等。基因治疗RP是目前的研究热点,包括修复致病基因、核酸治疗、RNA干扰技术等。基因治疗、干细胞移植、人工视网膜假体治疗RP已经进入临床试验阶段,为治疗该病带来了新的希望。本文就RP治疗的研究进展做一综述。
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| 关 键 词： | 视网膜色素变性 治疗 基因 移植 |
Recent advances in retinitis pigmentosa therapy |
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| ZHOU Peng-Yi
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PENG Guang-Hua.Recent advances in retinitis pigmentosa therapy[J].Recent Advances in Ophthalmology,2012,32(5):493-496. |
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| Authors: | ZHOU Peng-Yi PENG Guang-Hua |
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| Institution: | From the Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,Henan Province,China |
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| Abstract: | Retinitis Pigmentosa(RP) is a heterogeneous group of inherited retinal disorders characterized by photoreceptor or retinal pigment epithelial degeneration and apoptosis.At present,there is no clinically effective treatment for RP,and it becomes the hot issue in international research.Current treatment for RP is still in the exploratory research period,including gene therapy,pharmacologic treatment,transplantation treatment and neuro-prosthetic devices.Gene therapy for RP is the hot spot,including repair disease genes,nucleic acid therapy,RNA interference technology and other methods.Those methods have entered the clinical trials stage,which bring new hopes for the treatment of RP.This article reviews the recent advances in treatment of RP. |
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| Keywords: | retinitis pigmentosa therapy gene transplantation |
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