疏水性和肝素修饰亲水性丙烯酸酯人工晶状体的临床应用效果对比

目的比较疏水性丙烯酸酯人工晶状体(intraocular lens,IOL)与肝素修饰的亲水性丙烯酸酯IOL的临床应用效果。方法 121例(152眼)白内障患者接受了白内障超声乳化摘出联合IOL植入术,其中64眼植入疏水性Sensar AR40e丙烯酸酯IOL为Sensar AR40e组,88眼植入肝素修饰的亲水性HQ201hep丙烯酸酯IOL为HQ201hep组。记录并比较2组术后3d裸眼视力、术后2a最佳矫正视力及后囊膜混浊(posterior capsular opacification,PCO)的发生情况。结果 2组间术后3d裸眼视力及术后2a最佳矫正视力的差异均无统计学意义(χ2=1.066、1.912,P=0.785、0.591)。术后2a PCO的发生率,Sensar AR40e组为15.63%(10/64),HQ201hep组为21.59%(19/88);2级和3级PCO的发生率Sensar AR40e组为1.56%(1/64),HQ201hep组为7.95%(7/88),2组间比较差异均无统计学意义(χ2=3.118、3.036,P=0.374、0.081)。进一步分析发现,在2组60岁以上患者的148眼中,Sensar AR40e组的1.56%(1/64)和HQ201hep组的3.57%(3/84)发生了2级或3级PCO,2组比较差异无统计学意义(χ2=0.055,P=0.814);Sensar AR40e组1.56%(1/64)和HQ201hep组2.38%(2/84)接受了Nd:YAG激光后囊膜切开术,2组比较差异无统计学意义(χ2=0.000,P=1.000)。结论疏水性丙烯酸酯IOL与肝素修饰的亲水性丙烯酸酯IOL植入术后的视力和PCO程度无统计学差异。

Clinical comparison between hydrophobic and heparin surface modified hydrophilic acrylic intraocular lenses

Objective To compare the clinical effects of hydrophobic acrylic intraocular lens(IOL) with heparin surface modified(HSM) hydrophilic acrylic IOL.Methods One hundred and fifty-two eyes of 121 patients with cataract received phacoemulsification and acrylic foldable IOL implantation,including hydrophobic acrylic IOL Sensar AR40e(64 eyes,Sensar AR40e group) and HSM hydrophilic acrylic IOL HQ201hep(88 eyes,HQ201hep group).Uncorrected visual acuity at postoperative 3 days and best corrected visual acuity at postoperative 2 years were measured,while incidence of posterior capsule opacification(PCO) at postoperative 2 years was assessed in two groups.Results There was no statistical difference in uncorrected visual acuity at postoperative 3 days and best corrected visual acuity at postoperative 2 years between two groups(χ2=1.066,1.912,P=0.785,0.591).At postoperative 2 years,the incidences of PCO were 15.63%(10/64)in Sensar AR40e group and 21.59%(19/88)in HQ201hep group,and the incidences of PCO with grades 2 and 3 were 1.56%(1/64) in Sensar AR40e group and 7.95%(7/88) in HQ201hep group,there was no statistical difference between two groups(χ2=3.118,3.036,P=0.374,0.081).Moreover,in 148 eyes of patients more than 60 years old of two groups,the incidences of PCO with grades 2 and 3 were 1.56%(1/64) in Sensar AR40e group and 3.57%(3/84) in HQ201hep group,there was no statistical difference(χ2=0.055,P=0.814);Nd:YAG capsulotomy was performed in 1.56%(1/64) in Sensar AR40e group and 2.38%(2/84) in HQ201hep group,there was no statistical difference(χ2=0.000,P=1.000).Conclusion There is no statistical difference in postoperative visual acuity and degree of PCO between hydrophobic acrylic IOL and HSM hydrophilic acrylic IOL.