Growth hormone treatment increases CO2 response, ventilation and central inspiratory drive in children with Prader-Willi syndrome |
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Authors: | A C Lindgren L G Hellström E M Ritzén J Milerad |
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Institution: | (1) Department of Woman and Child Health, Paediatric Endocrinology Unit, Karolinska Hospital, S-171 76 Stockholm, Sweden e-mail: Ann.Christin.Lindgren@kbh.ki.se, Tel.: +46-8-51777565, Fax: +46-8-51775128, SE |
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Abstract: | We studied whether the beneficial effects of growth hormone (GH) treatment on growth and body composition in PWS are accompanied
by an improvement in respiratory function. We measured resting ventilation, airway occlusion pressure (P0.1) and ventilatory response to CO2 in nine children, aged 7–14 years, before and 6–9 months after the start of GH treatment. During GH treatment, resting ventilation
increased by 26%, P0.1 by 72% and the response to CO2 by 65% (P < 0.002, <0.04 and <0.02, respectively). This observed increase in ventilatory output was not correlated to changes in body
mass index.
Conclusion Treatment of children with Prader-Willi syndrome (PWS) seems to have a stimulatory effect on central respiratory structures.
The observed increase in ventilation and inspiratory drive may contribute to the improved activity level reported by parents
of PWS children during growth hormone therapy.
Received: 28 April 1998 / Accepted: 6 April 1999 |
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Keywords: | CO2 Growth hormone Hypoventilation Prader-Willi syndrome Ventilation |
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