埃索美拉唑联合莫沙必利治疗胃食管反流病的疗效观察

目的观察埃索美拉唑联合莫沙必利治疗胃食管反流病(gastro-esophageal reflux disease,GERD)的疗效。方法将符合GERD诊断标准的86例患者按就诊先后顺序分为治疗组(42例)和对照组(44例),治疗组给予埃索美拉唑(20 mg,每日2次)联合枸橼酸莫沙必利(5 mg,每日3次)治疗,对照组仅给予埃索美拉唑20 mg,每日2次,两组疗程均为8周。观察临床症状的缓解情况和胃镜下食管炎的愈合情况。结果治疗组临床症状改善情况及胃镜检查食管炎的愈合情况明显优于对照组(P<0.05)。结论埃索美拉唑联合莫沙必利治疗GERD疗效优于单用埃索美拉唑。

Effect observation of Esomeprazole combined with mosapride in the treatment of gastroe-sophageal reflux disease

Objective To investigate the elinieai effect of Esomeprazole combined with Mosapride in patients with gastro-esopbageal reflux disease （GERD）. Methods Eighty-six patients with GERD were divided into two groups：the treatment group 42 cases （ Esomeprazole 20 mg, two times per day, combined with Mosapride 5 mg, three times per day）, and the control group 44 cases （ only Es- omeprazole 20 mg, two times per day） , and all patients were treated for 8 weeks. Remission of clinical symptoms and endoscopic healing of esophagitis were observed. Results The clinical symptoms and endoscopic healing of es@agitis improved more obviousely in pa- tients given Esomeprazole combined with Mosapride than the control group （ P 〈 0.05 ）. Conclusion The clinical effect of Esomeprazole combined with Mosapride is more affirmative than only Esomeprasole in patients with GERD.