| 实验性非压迫腰椎间盘髓核突出大鼠模型的建立 |
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| 引用本文： | 陆志东,金群华,陈志荣.实验性非压迫腰椎间盘髓核突出大鼠模型的建立[J].宁夏医科大学学报,2003,25(3):167-169,172. |
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| 作者姓名： | 陆志东 金群华 陈志荣 |
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| 作者单位： | 宁夏医学院附属医院骨科 银川750004
(陆志东，金群华)，宁夏医学院附属医院骨科 银川750004(陈志荣) |
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| 摘 要： | 目的：设计一种新的非压迫性腰椎间盘髓核突出动物模型。方法：选择7只Sprague-Dawley(SD)雄性大鼠，将自身尾椎髓核混悬液注射到腰椎硬膜外腔建立动物模型。测量术前、术后3、5、7、9d大鼠后肢机械刺激缩爪阈值。结果：在没有明显机械压迫下，造模后大鼠出现明显的痛觉过敏反应。结论：本模型简单、可靠、费用低廉，为进一步研究腰椎间盘突出症和根性神经痛提供了理想的动物模型。
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| 关 键 词： | 腰椎间盘髓核突出 痛觉过敏 动物模型 根性神经痛 |
| 文章编号： | 1005-8486(2003)03-0167-04 |
Establishment of Non- compressive Model Rat for Studying Lumbar Nucleus Pulposus prolapse - related Radiculalgia |
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| LU Zhi-dong,JIN Qun-hua,CHEN Zhi-rong.Establishment of Non- compressive Model Rat for Studying Lumbar Nucleus Pulposus prolapse - related Radiculalgia[J].Journal of Ningxia Medical College,2003,25(3):167-169,172. |
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| Authors: | LU Zhi-dong JIN Qun-hua CHEN Zhi-rong |
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| Abstract: | Objective: Establishing non-compressive model rat with imitating lumbar nucleus pulposus prolapse to study the mechanism of nerve root pain. Methods: Seven SD rats were used. The suspension consisting of nucleus pulposus of coccygeal vertebra and normal saline was heteroautogenously transplanted into the cavum epiduralis of individual rat, creating a type of non-compressive model with nucleus pulposus autograft. The posterior limb's claws-retracting threshold for mechamical stimulation was determined shortly before and after operation on day 3 ,day 5, day 7 and day 9, respectively. Results: Without extrinsically overt mechanical compression of lumbar vertebrae, the murine model displayed hyperalgesic response. Conclusion: The established non-compressive model rat is an ideal and reliable method to study the mechanism of disc herniation-related radiculalgia. |
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| Keywords: | herniation of lumbar intervertebral disc nucleus pulposus hyperalgesia animal model |
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