Dependence of histamine release from rat mast cells on adenosine triphosphate |
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Authors: | Torben Johansen Nirmal Chakravarty |
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Institution: | (1) Dept. of Pharmacology, Odense University, Odense, Denmark |
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Abstract: | Summary using pure populations of rat mast cells, the relation of the ATP content of the cells to histamine release induced by compound 48/80 has been studied. Variable ATP levels in the mast cells have been produced by incubation with appropriate concentrations of oligomycin.The dose-response curves of oligomycin for the inhibition of histamine release and for the reduction in the ATP content of the mast cells are similar. The concentration required for 50% inhibition of histamine release is, however, higher than that for 50% reduction of the ATP level.Comparative study of the reduction of the ATP content and the inhibition of histamine release in samples of the same suspension of mast cells shows a linear relation between 10 to 90% inhibition of histamine release and 40 to 95% inhibition of ATP synthesis.The observations support the hypothesis that ATP is involved in the process of histamine release from mast cells induced by compound 48/80. |
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Keywords: | Histamine Mast Cells ATP Oligomycin Compound 48/80 |
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