| ~(99m)Tc-标记新肝胆显象剂的合成和动物实验 |
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| 引用本文： | 周锡瑞,陈绍亮,陈国辉,徐勤丰. ~(99m)Tc-标记新肝胆显象剂的合成和动物实验[J]. 复旦学报(医学版), 1993, 0(5) |
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| 作者姓名： | 周锡瑞 陈绍亮 陈国辉 徐勤丰 |
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| 作者单位： | 上海医科大学药学院合成药物化学教研室，中山医院核医学研究室，上海医科大学药学院合成药物化学教研室，上海医科大学 1983届学生 |
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| 基金项目： | 国家自然科学基金,编号:3870851(1988～1990年) |
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| 摘 要： | 为寻找较胆红素竞争能力更强,肝胆显象更为清晰的放射性显象剂,作者根据构效关系原理,设计合成6个化合物。与临床应用的~(99m)Tc-Etifenin和更佳的~(99m)Tc-甲溴苯宁配对进行初步动物筛选,6个化合物的结果均优于~(99m)Tc-Etifenin,类似于~(99m)Tc-甲溴苯宁。
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| 关 键 词： | ~(99m)To-标记肝胆显象剂 芳氨甲酰甲基亚氨二乙酸类 吡哆氨基酸类 甲溴苯宁 吡哆甲基色氨酸 甲氧溴苯宁 |
SYNTHESIS AND ANIMAL EXPERIMENT OF ~(99m)Tc-LABELED HEPATOBILIARY IMAGING AGENTS |
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| Zhou Xi-Rui,Ohen Shao-Liang,Ohen Guo-Hui,Xu Qin-Feng. SYNTHESIS AND ANIMAL EXPERIMENT OF ~(99m)Tc-LABELED HEPATOBILIARY IMAGING AGENTS[J]. Fudan University Journal of Medical Sciences, 1993, 0(5) |
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| Authors: | Zhou Xi-Rui Ohen Shao-Liang Ohen Guo-Hui Xu Qin-Feng |
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| Abstract: | Six new compounds based on the principle of isosterism and hybridization had been synthesized. Mothobrofenin was prepared by reduction of nitromesity-lene, followed by bromination and acylation with nitrilotriacetic acid. The 99mTc-complexes of these compounds were prepared by stannous chloride reduction of sodium pertechnetate in aqueous solution. These labeled compounds, being similar to 99mTc-mebrofenin, all were quick in the uptake by the liver cells, rapidly cleared off from the blood in mice, and had higher cumulative nepatobiliary excretion rates than Tc-99m-EHlDA. |
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| Keywords: | ~(89)mTc-labeled hepatobiliary imaging agent arylcarbamoylme-thyliminodiacetic acids pyridoxylaminates mebrofenin pryidozyl-5-methyltrypto-phan methobrofenin |
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