1850株病原菌耐药性分析

目的了解感染患者病原菌分布及常见致病菌的耐药情况。方法对医院2006年1-12月细菌培养和药敏试验的结果进行回顾性分析和统计。结果共分离病原菌1850株,其中革兰阳性(G )菌620株,占33.51%;革兰阴性(G-)菌1230株,占66.49%;主要包括大肠埃希菌(25.8%)、表皮葡萄球菌(8.1%)、肺炎克雷伯菌(7.5%)、金黄色葡萄球菌(7.2%)等;药敏试验结果显示,所分离的G 菌对万古霉素、替考拉宁、呋喃妥因高度敏感,对利福平敏感性较好,对其他抗菌药物敏感性不佳,G-菌对亚胺培南高度敏感,对哌拉西林/他唑巴坦和第三代头孢类药物也较敏感。结论分离菌株耐药现象普遍存在,临床应重视病原学检查,开展细菌耐药性监测,合理使用抗菌药物。

Bacterial Resistance of 1850 Pathogen Strains

OBJECTIVE To acquaint pathogen distribution of infection and present drug-resistance conditions of the commonly encountered pathogens.METHODS The statistics of the antimicrobial susceptibility testing of all the clinical isolates from Jan to Nov 2006 in our hospital was condncted.RESULTS Totally 1850 bacteria strains were isolated.From them 620(33.51%) were Gram-positive bacteria,1230(66.49%) were Gram-negative bacteria,25.8% of which were Escherichia coli,8.1% of which were Staphylococcus epidermidis,7.5% were Klebsiella pneumonice and 7.2% were MSSA;Statistics of drug sensibility test suggested,Gram-positive cocci isolated from the clinical issue be highly sensitive to vancomycin,teicoplanin and nitrofurantoin.They were still sensitive to rifampicin.and lower sensitive to other antibiotics.Gram-negatives were high sensitive to imipenem.They were still sensitive to piperacillin/tazobactam and the third-generation cephalosporins.CONCLUSIONS The drug resistance of the isolates is severe.It is suggested that there be ungent need for surveillance of bacterial resistance and rational use of antimicrobial agents be emphasized during clinical therapy.