原发性卵巢癌组织中肺耐药相关蛋白的表达及其临床价值

目的研究肺耐药相关蛋白(LRP)在原发性卵巢癌组织中的表达状况,探讨其在卵巢癌化学治疗耐药中的作用机制,以及与临床病理生物学特征间的相关性。方法应用免疫组织化学技术对52例原发性卵巢癌、12例卵巢良性肿瘤和10例正常卵巢组织中肺耐药相关蛋白表达状况进行测定。结果肺耐药相关蛋白(LRP)在卵巢癌组织中阳性表达率均显著高于良性肿瘤和正常组织对照组。LRP阳性表达与卵巢癌组织类型、肿瘤分化程度无关,但与临床病理分期及化疗敏感性相关显著,Ⅲ、Ⅳ期组织中LRP阳性表达率显著高于Ⅰ、Ⅱ期。结论LRP在原发性卵巢癌中存在较稳定的表达。检测LRP对前瞻性预测化疗药物敏感性和判断化疗疗效具有一定的临床指导价值。

CLINICAL SIGNIFICANCE OF LUNG RESISTANT-RELATED PROTEIN EXPRESSION IN OVARIAN CARCINOMA

Objective To investigate the clinical significance of lung resistant-related protein(LRP) expression in ovarian carcinoma and evaluate its roles in chemoresistance of ovarian carcinoma.Methods The expression of LRP in 52 cases of ovarian carcinoma(12 benign ovarian tumors and 10 normal controls) were determined by using immunohistochemistry.The relationship between the expression of LRP and clinical pathological features was analyzed.All the patients did not received chemotherapy or radiotherapy before operation.Results The positive expression of LRP in patients with ovarian carcinoma was higher than that of the benign tumors and normal controls.A significant correlation was shown between LRP and and clinical stage.No significant differences with the expression of LRP were found in relation to the histopathology and differentiated degree.Conclusion LRP expression in ovarian carcinoma is really related to multidrug resistance,which may be helpful in predicting chemosensitivities and guiding postoperative therapeutic choices.