| 小儿葫芦散对大鼠毒性的实验研究 |
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| 引用本文： | 白瑶,朴晋华.小儿葫芦散对大鼠毒性的实验研究[J].山西中医学院学报,2006,7(6):11-12. |
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| 作者姓名： | 白瑶 朴晋华 |
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| 作者单位： | 1. 山西中医学院,山西,太原,030024
2. 山西省药品检验所,山西,太原,030001 |
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| 基金项目： | 山西省科技攻关项目(项目编号:051076-4) |
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| 摘 要： | 目的:观察小儿葫芦散对大鼠的毒性反应,对小儿葫芦散作临床安全性再评价。方法:选用Wister大鼠为受试动物,观察小儿葫芦散以生药3g/kg、6g/kg的剂量1次/d给药,连续4w以观察其毒性反应。结果:给药期间动物的一般情况、体重与生理盐水组比较无显著性差异。实验4w及恢复期血常规和血液生化指标给药组与对照组比较无显著性差异(P>0.05)。动物尸检各主要脏器未见明显病理改变,对照组动物脏器系数和各给药组相比无明显差异,且均在正常范围,各器官组织未见病理学改变。结论:小儿葫芦散连续4w给大鼠灌胃给药未出现任何毒性反应。
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| 关 键 词： | 小儿葫芦散 大鼠 毒性 实验研究 |
| 文章编号： | 1671-0258(2006)06-0011-02 |
| 收稿时间： | 09 23 2006 12:00AM |
| 修稿时间： | 10 20 2006 12:00AM |
Experimental Study of Toxicity of Xiaoer Hulu Powder on Wister Rats |
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| Bai Yao,Piao Jinhua.Experimental Study of Toxicity of Xiaoer Hulu Powder on Wister Rats[J].Journal of Shanxi College of Traditional Chinese Medicine,2006,7(6):11-12. |
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| Authors: | Bai Yao Piao Jinhua |
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| Institution: | Shanxi College of TCM, Taiyuan Shanxi 030024 |
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| Abstract: | Objective:To observe the toxicity of Xiaoer Hulu powder on Wister rats. Method: 72 Wister rats were randomly divided into normal group, Xiaoer Hulu powder group 1(3 g/kg), group 2(6 g/kg). Xiaoer Hulu powder group 1 and group 2 were given Xiaoer Hulu powder by stomach perfusing respectively once a day for four weeks. Then body weighs, hematological indexes, biochemical indexes of the blood and pathological changes of rats were observed. Result: The diffrerence of body weighs, hematological indexes, biochemical indexes of the blood, pathological changes and organ coefficients were not obvious between Xiaoer Hulu powder groups and normal group. Conclusion: Xiaoer Hulu powder had no toxicity on Wister rats. |
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| Keywords: | Xiaoer Hulu powder rats toxicity experimental study |
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