| 白芍总甙降低小鼠和大鼠体温作用及其机理初步探讨 |
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| 引用本文： | 王永祥,徐叔云,陈鹏. 白芍总甙降低小鼠和大鼠体温作用及其机理初步探讨[J]. 中国药理学通报, 1988, 0(3) |
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| 作者姓名： | 王永祥 徐叔云 陈鹏 |
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| 作者单位： | 安徽医科大学药理教研室 合肥(王永祥，徐叔云)，安徽合肥钢铁公司医院 安徽中医学院中药系87届毕业生(陈鹏) |
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| 摘 要： | 白芍总甙(5～40mg/kg,ip)呈剂量依赖式地降低小鼠和大鼠正常体温,作用高峰在1/2～1h,其降温作用受环境温度影响。但白芍总甙(40mg/kg,ip或iv)对正常豚鼠和家兔无明显降温作用。大鼠侧脑室微量注射白芍总甙(2、4mg/kg)有明显降温作用。H_1-组胺受体阻断剂氯苯吡胺(10、20mg/kg,sc)可明显拮抗白芍总甙对大鼠和小鼠的降温作用。
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| 关 键 词： | 白芍总苷 降温 环境温度 侧脑室 氯苯吡胺 |
HYPOTHERMAL EFFECT OF TOTAL GLUCOSIDES OF PAEONY ROOT AND PRELIMINARY STUDY OF ITS MECHANISM |
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| Wang Yongxiang,Chen Peng , Xu Shuyun. HYPOTHERMAL EFFECT OF TOTAL GLUCOSIDES OF PAEONY ROOT AND PRELIMINARY STUDY OF ITS MECHANISM[J]. Chinese Pharmacological Bulletin, 1988, 0(3) |
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| Authors: | Wang Yongxiang Chen Peng & Xu Shuyun |
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| Abstract: | Total glucosides of paeony root ( TGPs ) ( 5 ~40mg/kg, ip ) had a dose-related hypothermal effect in mice and rats, which was related to the environment temperature. But TGPs ( 40mg/kg, ip or iv ) showed no significant hypothermal effect in guinea-pigs or rabbits. TGPs ( 2, 4 mg/kg, icv ) had a potential hypothermal effect in rats. Chlopheniramine had antagonist effect on hypothermal effect of TGPs in mice and rats. |
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| Keywords: | TGPs Hypothermia Environment temperature Lateral ventricie Chlopheniramine |
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