Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. |
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| Authors: | Anouk C Vedder Jan J Weening Raymond T Krediet |
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| Institution: | Department of Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands. |
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| Abstract: | |
Introduction
| Heavy chain deposition disease (HCDD) is a rare manifestationof plasma cell dyscrasia. Only 11 cases have been describedin the literature 1]. The clinical picture is variable, butin all patients renal biopsy showed a nodular sclerosing glomerulopathy1–5]. We report a patient with rapidly progressive glomerulonephritisin whom the renal biopsy showed mainly intracapillary proliferativeglomerulonephritis due to HCDD.
Case
| The patient is a 55-year-old musician with an uneventful medicalhistory except ankylosing spondylitis diagnosed at the age of47. Six weeks before admission he noticed foamy urine, at 2weeks he developed generalized swelling, dyspnoea and a severeheadache. Upon admission
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| Keywords: | heavy chain deposition disease intracapillary proliferative glomerulonephritis plasmacell dyscrasia renal biopsy renal failure |
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