异丙酚辅助腰硬联合麻醉在腹腔镜疝修补术中气腹时患者体动反应的半数有效效应室靶浓度

目的:确定异丙酚辅助腰麻联合硬膜外麻醉(combined spinal-epidural anesthesia,CSEA)在建立气腹时患者体动反应的半数有效效应室靶浓度(EC50).方法:选择异丙酚辅助行腹腔镜完全腹膜外疝修补术(totally extraperitoneal prosthesis,TEP)患者50例,...

The half-effective target effect-site concentration of propofol required to inhibit the body movement during pneumoperitoneum at totally extraperitoneal prosthesis under combined spinal-epidural anesthesia

Objective:To determine the half-effective target effect-site concentration(EC50) of propofol required to inhibit the body movement during pneumoperitoneum at totally extraperitoneal prosthesis(TEP) under combined spinal-epidural anesthesia(CSEA).Methods:Fifty ASA Ⅰ or Ⅱ patients of both sexes,BMI<30 kg/m2,undergoing laparoscopic TEP were randomly divided into 5 groups according to the different target effect-site concentration of propofol(n=10):group S1(1.0 ng/ml),group S2(1.5 ng/ml),group S3(2.0 ng/ml),group S4(2.5 ng/ml),group S5(3.0 ng/ml).The pneumoperitoneum was established as soon as the patients lost consciousness,pneumoperitoneum pressure was about 10 mmHg.The response was defined as positive when body movement occurred(cough and swallowing were excluded).The EC50 of propofol required to inhibit the body movement during 10 mmHg CO2 pneumoperitoneum and 95% confidence interval(CI) were calculated by Bliss method.Results:The EC50 of propofol required to inhibit the body movement during 10 mmHg CO2 pneumoperitoneum at laparoscopn TEP under CSEA is 2.23 ng/ml and 95% CI was 1.80-3.31 ng/ml.Conclusions:The EC50 of propofol required to inhibit the body movement during pneumoperitoneum at laparoscopic TEP under CSEA is 2.23 ng/ml.