低剂量MPTP致雌鼠黑质听觉P50诱发电位动态变化的实验研究

目的:功能学角度了解低剂量MPTP对雌鼠黑质听觉P50诱发电位的动态影响及帕金森病动物模型旋转行为的出现与黑质听觉P50诱发电位的关系。方法:45只大鼠随机分为三组:(1)正常对照组;(2)MPTP致帕金森病模型组;(3)生理盐水对照组。动态监测术后第7至14天MPTP型帕金森病动物模型黑质听觉P50诱发电位。结果:MPTP组的P50T/C值在第11~14天均较正常组及生理盐水溶剂对照组(I NT-Saline组)降低,且有统计学意义(P<0.01)。结论:低剂量MPTP可渐进性引起正常雌鼠黑质听觉P50诱发电位降低,且在帕金森病动物模型黑质听觉P50诱发电位降低的同时出现旋转行为。

The Experiment of Dynamic Change the Abnormal P50 Auditory Evoked Potential of Substantia Nigra Damaged by Low-Dose MPTP in Female Rats

Objective: From the functional view, investigate the dynamic change of P50 auditory evoked potential induced by low dose MPTP in substantia nigra of female rats and the relationship between the revolving action of animal model of Parkinson disease induced by low dose MPTP and P50 auditory evoked potential of substantia nigra.Method: 45 health adult female Sprague-Dawley rats were randomly divided into three groups:1.normal control group;2.MPTP Parkinson's disease model group;3. solution control group. Then dynamic investigation the animal model of Parkinson's disease induced by low dose MPTP during after operation day 7-14.Results: The T/C ratio of P50 is significantly low in low-dose MPTP group during after operation day 11-14 as compared to normal control group(P<0.01) and solution control group(P<0.01).Conclusion: Directly injection of low-dose MPTP into unilateral substantia nigra can gradually result in decreaseing P50 auditory evoked potential of substantia nigra in normal female rats ;along with the P50 auditory evoked potential decreaseing and animal model of Parkinson disease induced by low dose MPTP can revolve through injection apomorphine at the same time.