乳腺肿瘤雌、孕激素受体表达与细胞增殖

目的：观察乳腺肿瘤雌、孕激素受体表达与细胞增殖的关系。方法：用免疫细胞化学技术（ＡＢＣ法）对经病理确诊２５５例恶性和６６０例良性乳腺肿瘤进行了ＥＲ、ＰＲ、ｃ－ｅｒｂＢ－２、ｐ５３基因蛋白表达和Ｋｉ－６７抗原检测。结果：良、恶性乳腺肿瘤间，ＥＲ、ＰＲ阳性率均有极显著差异。良性肿瘤组中，ＥＲ＋ＰＲ＋组和ＥＲ－ＰＲ－组间差异有显著性；ｐ５３表达率在ＥＲ、ＰＲ阴、阳性组间差异有显著性；ｃ－ｅｒｂＢ－２表达

The Relationship between Expression of Estrogen and Progesterone Receptors and Cell Proliferation in Breast Tumors

ObjectiveTostudy the relationship between expression of estrogen receptor (ER) and progesteronereceptor (PR) and cell proliferation． MethodsThe expression of ER，PR，c－erbB－2，p53and Ki－67 were measured by immunoeytochemistry in 255 malignant and 660 benign breasttumors which all confirmed pathologically． ResultsIt showed that there wassignificant difference of expressions of ER and PR between malignant and benign tumors．In benign group，the expression of Ki－67 was significantly different between ER＋PR＋and ER－PR－ groups． In malignant group，the expression of Ki－67 in PR negative andER－PR－ groups were higher than those in PR positive and ER＋PR＋ groups． Theexpression of p53 product was significantly different in ER and PR expressions． Theexpression of c－erbB－2 was significantly different between ER＋ and ER－ groups，andthere was significant difference between ER－PR－ and ER＋PR＋ groups． ConclusionThestatus of ER and PR closely related with Ki－67，p53 and c－erbB－2 in breast tumors，butER and PR might have some different mechanisms on cell proliferation between benign andmalignant tumors． In malignant tumors，there is significant difference between c－erbB－2and ER or p53 and ERPR． No evidence shows that it relates with ER and PR variation．