梗阻性黄疸患者的内毒素血症及其对机体的影响

４９例梗阻性黄疸（梗黄）患者（实验组）和８１例无黄疸胆系疾病患者（对照组）围手术期外周血的内毒素（ＥＴ）检测结果表明，实验组：①术前ＥＴ阳性率明显高于对照组（Ｐ＜０．００１）；②术后１０～１２天夹闭Ｔ／Ｙ管后ＥＴ阳性率明显低于术前和夹管前（Ｐ＜０．００１）；③伴急性化脓性胆管炎（ＡＣＳＴ）的患者ＥＴ阳性率明显高于无ＡＣＳＴ的患者（Ｐ＜０．００１）。作者认为，本组梗黄患者中出现的肾功能障碍、胃肠道出血以及２例患者的死亡，可能部分与内毒素血症有关。

ENDOTOXEMIA IN PATIENTS WITH OBSTRUCTIVEJAUNDICE AND ITS EFFECT ON THE ORGANISM

ndotoxin (ET) in the peripheral blood from 49 patients with obstructive jaundice (OJ)and 81 patients with nonicteric biliary tract diseases (NIBD) in the perioperative period wasassayed. The results showed that in patients with OJ (1) the preoperative blood ET positiverate was significantly higher than that in patients with NIBD (P<0. 001 ) , (2)clamping ofthe T/Y tubes 10-12 days postoperatively resultedin a much lower blood ET positive rateas compared with that before operation as well as before clamping (P<0. 001) , (3)blood ETpositive rate in patients with acute suppurative cholangitis was much higher than in patientswithout this complication (P<0. 001). It is considered by the authors that in the presentstudy , endotoxemia is at least partly responsible for the renal function disturbance, gastrointestialheniorrhage and 2 cases of death in patients with OJ.