| 环氧化酶-2在肾癌中表达的研究 |
| |
| 引用本文： | 崔书平,霍红旭,黑兰荪,常学良.环氧化酶-2在肾癌中表达的研究[J].肿瘤防治研究,2004,31(11):683-684,687. |
| |
| 作者姓名： | 崔书平 霍红旭 黑兰荪 常学良 |
| |
| 作者单位： | 1. 050040 石家庄,解放军第260医院泌尿外科
2. 河北医科大学附属第二医院泌尿外科 |
| |
| 摘 要： | 目的探讨COX2与肾透明细胞癌的关系及临床意义。方法应用免疫组化技术检测35例肾透明细胞癌标本中COX2的表达,分析其与肾透明细胞癌的临床分期、病理分级及浸润、转移的关系。结果肾透明细胞癌COX2阳性表达率为68.6%,对照组正常肾组织阳性表达率20%,二者差别有显著性意义(P<0.05)。COX2的表达与肾透明细胞癌临床分期显著相关,PT3～4期明显高于PT12期(P<0.05),不同病理分级肾透明细胞癌的表达差别无显著性意义。结论COX2在肾透明细胞癌的发生发展中起重要作用,与肾透明细胞癌的浸润、转移相关。
|
| 关 键 词： | 肾肿瘤 COX-2表达 透明细胞癌 |
| 文章编号： | 1000-8578(2004)11-0683-02 |
| 收稿时间： | 2003-4-24 |
| 修稿时间： | 2004-3-30 |
Expression of Cyclooxygenase-2 in Human Renal Cell Carcinoma |
| |
| CUI Shu ping ,HUO Hong xu ,HEI Lan sun ,CHANG Xue liang.Expression of Cyclooxygenase-2 in Human Renal Cell Carcinoma[J].Cancer Research on Prevention and Treatment,2004,31(11):683-684,687. |
| |
| Authors: | CUI Shu ping HUO Hong xu HEI Lan sun CHANG Xue liang |
| |
| Institution: | CUI Shu ping 1,HUO Hong xu 2,HEI Lan sun 2,CHANG Xue liang 2 1.Department of Urology,PLA No. 260 Hospital,Shijiazhuang 050040,China, 2.Department of Urology,Second Affiliated Hospital,Hebei Medical University |
| |
| Abstract: | Objective To study the expression of cyclooxygenase 2 (COX 2) in human renal cell carcinomas(RCCs) and to evaluate its clinical significance. Methods The expression of COX 2 was observed in 35 RCCs by immunohistochemical staining of SP method.Results COX 2 specific proteins were found in 24 of 35 RCC specimens, while in control renal tissues were 4 of 20. Expression of COX 2 in RCCs was significantly higher than that in control renal tissues( P < 0.05 ). There are statistical significances between the PT 1 2 and PT 3 4 stage cases( P < 0.05 ), but no correlation was found between COX 2 and tumor grading.Conclusion The results suggested that COX 2 over expression plays a role in development and invasion of RCCs. |
| |
| Keywords: | Kidney neoplasms Expression of cyclooxygenase-2 Renal cell carcinomas |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
| 点击此处可从《肿瘤防治研究》下载免费的PDF全文 |
|
