The effects of two 21-aminosteroids on overt infarct size 48 hours after middle cerebral artery occlusion in the rat |
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Authors: | Thomas Beck and Gerhard Wilhelm Bienlenberg |
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Affiliation: | aDepartment of Pathology, P & S 15-401, College of Physicians and Surgeons, Columbia University, New York U.S.A. bInstitut für Pharmakologie und Toxikologie, Fachbereich Pharmazie, Philipps Universität, Marburg F.R.G. |
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Abstract: | The lipid peroxidation inhibitors U74006F (21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-16-methylpregna-1,4,9]-(11)-triene-3, 20-dione) and U7452E (21-[4-(3-ethylamino-2-pyridinyl)-1-piperazinyl]-16-methylpregna-1,4,9]-(11)-triene-3,20-dione) were tested for cerebroprotective properties in the rat. Focal cerebral ischemia was induced by irreversible occlusion of the middle cerebral artery (MCA-O). The 21-aminosteroids U74006F (1 mg/kg or 10 mg/kg, i.p.) and U75412E (1 mg/kg or 30 mg/kg, i.p.) were injected 30 min prior and 2, 6, and 24 h after MCA-O. The higher doses of U74006F or U75412E caused reductions in cortical infarct size ranging from 28 to 34%. The data suggest the 21-aminosteroids to be mildly effective after irreversible occlusion of the MCA but possibly to be more beneficial as part of a combined drug therapy in conjunction with Ca2+ or NMDA antagonists. |
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Keywords: | Lipid peroxidation inhibitor U74006F U7412E Focal cerebral ischemia Rat |
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