子宫内膜中NO含量与功能失调性子宫出血的关系

目的探讨一氧化氮（NO）在子宫出血中可能起到的作用,以及NO与功能失调性子宫出血（功血）的关系.方法患者或正常人的子宫内膜和外周血中NO的测定用NO2-/NO3-的含量来反应,采用改良的镀铜镉粒还原法测定.结果 1）功血患者内膜组织中NO含量明显高于正常人,二者之间的差异有显著性意义（P〈0.05）.2）功血患者外周血中NO的含量与正常人没有明显差异（P〉0.05）.3）功血患者子宫内膜各种病理类型间两两比较都没有明显的差异（P〉0.05）.结论在功血患者的子宫内膜组织中NO的含量明显高于正常人,提示NO是通过改变子宫局部微环境来影响子宫出血的,子宫内膜NO含量的增高可导致子宫出血时间过长或流血过多,但子宫内膜的病理类型与NO含量无密切关系.

The Relation between Nitric Oxide in Endometrium and Error Functional Uterine Bleeding

Objective To explore the relation between nitric oxide (NO) and error functional uterine bleeding (DUB).Methods We determined the concentration of NO_2-/NO_3-in the endometrium and blood samples that had been worked to reflect the concentration of NO by improving cuprum electroplated cadmium method.Results:Independent-samples T test,SSPS 12.0.Results 1)The NO amounts in endometrial samples of study group (n=60) were higher than those of the corresponding controls (n=19) (P< 0.05).2)The NO amounts in blood samples of study group (n=25) were no higher than that of the corresponding controls (n=32) (P> 0.05).3)There was no significant difference between any two groups of different pathological types of the three groups in the study group of endometrium (P> 0.05). Conclusions NO affects the uterine bleeding by influencing the local micro-circumstance of uterine,higher NO amounts lead to persistent bleeding of uterine or menorrhagia.Yet there may be no closed relation between the NO amounts and pathological type of endometrium.