放射性131碘治疗对甲状腺癌患者白细胞的影响

目的：探讨放射性131碘治疗分化型甲状腺癌时，辐射对患者白细胞的影响。方法：利用全自动血液分析仪，对40例健康人、80例分化型甲癌患者131I治疗前、治疗后7天、治疗后3个月白细胞进行检测并分析研究。结果：各组131I治疗后7天自细胞均升高（P〈0．05），其中粒细胞明显升高（P〈0．01），淋巴细胞降低（P〈0．05），单核细胞略降低（P〉0．05）；治疗后3个月白细胞包括粒细胞、淋巴细胞、单核细胞均接近正常，与对照组比较无明显差异（P〉0．05）。结论：利用131I治疗分化型甲状腺癌，辐射对患者白细胞有一定影响，治疗后7天白细胞升高，其中粒细胞明显升高，淋巴细胞降低，单核细胞略降低；治疗后3个月白细胞包括粒细胞、淋巴细胞、单核细胞均接近正常。

Effects of 131 Iodine radiotherapy on leukocyte of thyroid carcinoma patients

Objective：To observe the effects of 131I radiotherapy radiation on leukocyte of thyroid carcinoma pa- tients. Methods： The level of leukocyte （ include granulocyte, lymphocyte and monocyte） was measured by full auto- matic hemocyte analyzer in 40 normal subjects and 80 cases of thyroid carcinoma patient （before ln I radiotherapy,7 days and 3 months after 131I radiotherapy）. The changes of leukocyte level （include granulocyte, lymphocyte and mon- ocyte） were compared with that of normal group. Results： The level of leukocyte increased （ P 〈 0.05 ）, granulocyte in- creased obviously （ P 〈 0.01 ）, lymphocyte decreased （ P 〈 0.05 ）, monocyte, decreased lightly （ P 〉 0.05 ） 7 days after 131I radiotherapy. The level of leukocyte, granulocyte, lymphocyte and monocyte near normal group, after m I radiother- apy 3 months （P 〉 0.05 ）. Conclusion： The radiation effects of 131I radiotherapy on thyroid carcinoma patients have in- fluences on leukocyte. The level of leukocyte and granulocyte increased, lymphocyte and monocyte decreased 7 days after 131I radiotherapy, the level of leukocyte include granulocyte,lymphocyte and monocyte all are near normal group 3 months after 131I radiotherapy.