650株耐甲氧西林金葡菌的感染现状及耐药性分析

目的:分析江苏大学附属医院临床耐甲氧西林金黄色葡萄球菌(MRSA)的分布特点及耐药情况。方法:采用回顾性统计与分析方法,对2009年—2011年3年间临床送检的医院住院患者的各类标本中分离出的MRSA的病原菌,对其感染现状及耐药性进行分析。结果:3年间各类送检标本中分离出金黄色葡萄球菌984株,经筛选,其中MRSA为650株,占66.06%;痰与分泌物的标本中分离率为最高,占95.38%(620/650);MRSA的检出率呈上升趋势,并对大多数抗菌药物产生不同程度的耐药,尚未发现对万古霉素、替考拉宁、利奈唑胺的耐药菌株。结论:MRSA的检出率及耐药率逐年升高,且多重耐药性现象严重;应加强行政干预,采取多渠道、多部门联合的综合防控措施以遏制MRSA耐药率的增长。

Analysis of Nosocomial Infections and Drug Resistance Status in 650 Strains of MRSA

Objective： To analyze the clinical distribution characteristics and drug resistance of MRSA in the Hospital Affiliated to Jiangsu University. Methods： Using the statistics and analysis retrospectively,the distribution and resistance of MRSA pathogens isolated from various specimens of hospitalized patients during 2009-2011 are analysed. Results： During 2009-2011,984 strains of Staphylococcus aureus are isolated by the screening out of 650 strains of MRSA pathogens（66.06%）, the separation rate of phlegm and secretion is the highest （95.38%）, MRSA detection rate is in- creased year after year. Most of the antimicrobial drugs show varying degrees of resistance, the resistant strains of van- comycin, teicoplanin and linezolid are not found. Conclusion： The detection and resistance rates of MRSA increase year by year, and the multiple resistance is more serious. The administrative intervention measures should be taken to adopt multi-channel. Many departments jointly adopt comprehensive prevention and control measures of MRSA resis- tance to curb the growth.