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Monitoring healthy metabolic trajectories with nutritional metabonomics
Authors:Sebastiano Collino  Fran?ois-Pierre J Martin  Sunil Kochhar  Serge Rezzi
Institution:BioAnalytical Science, Metabonomics & Biomarkers, Nestlé Research Center, PO Box 44, CH-1000 Lausanne 26, Switzerland. Sebastiano.Collino@rdls.nestle.com
Abstract:Metabonomics is a well established analytical approach for the analysis of physiological regulatory processes via the metabolic profiling of biofluids and tissues in living organisms. Its potential is fully exploited in the field of "nutrimetabonomics" that aims at assessing the metabolic effects of active ingredients and foods in individuals. Yet, one of the greatest challenges in nutrition research is to decipher the critical interactions between mammalian organisms and environmental factors, including the gut microbiota. "Nutrimetabonomics" is today foreseen as a powerful approach for future nutritional programs tailored at health maintenance and disease prevention.
Keywords:GC (Gas Chromatography)  gut microbiota  MS (Mass Spectrometry)  metabolomics  metabonomics  metabotypes  NMR (Nuclear Magnetic Resonance) Spectroscopy  nutrimetabonomics  personalized nutrition  UPLC (Ultra Performance Liquid Chromatography)
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