α-硫辛酸对腔隙性脑梗死伴糖尿病患者认知功能的影响

目的:观察腔隙性脑梗死伴糖尿病患者的认知功能损害特点,并探讨α-硫辛酸对其认知功能的影响。方法:伴有糖尿病的腔隙性脑梗死患者60例,随机分配在A组(30例,每天静脉使用α-硫辛酸)和B组(30例,一般治疗)中,对照组(30例)选用健康体检人群。使用蒙特利尔认知评估量表(MOCA)分别对两组患者在发病后3天、3个月进行认知功能评估,并分别与正常对照组进行比较。结果:在脑梗死发病后3天,两组患者均出现视空间与执行功能、命名、延迟记忆、注意力和计算能力、语言、定向功能障碍,总分与对照组相比差异有显著性。在发病后3个月,使用硫辛酸组各项评分较一般治疗组高,总分及注意力、视空间与执行功能、定向力差异有统计学意义。结论:在伴有糖尿病的腔隙性脑梗死患者急性期认知损害广泛,α-硫辛酸对认知功能具有保护作用。

Effects of Alpha-lipoic Acid on Congnitive Function in Lacunar Infarction Patients with Diabetes Mellitu

Objective : To explore the characters of cognitive dysfunction for lacunar infarction(L I) with diabetes mellitus and the protective effects of alpha-lipoic acid.Methods : A total of 64LI patients with diabetes mellitus randomly divided into 2groups.Patients of group 1(n=30) were treated with alpha-lipoic acid.Patients of group 2(n=30) were assigned conventional therapy.The cognitive function of patients were evaluated with Montreal Cognitive Assessment(MOCA) at 3days and 3months after attack.An additional control group consisted of age-matched healthy(n=30).Results : Compared with controls,significant difference was found on the memory,name,language,orientation,attention,executive function,visuospatial and visuo-constructive function at 3days.Most cognitive domains were improved at 3months of group 1,scores of general MoCA,attention,visuospatial and visuo-constructive function and orientation were higher than those of group 2(P<0.05).Conclusions : In acute stage of LI,the cognitive impairment was extensive and severe.alpha-lipoic acid may improve congnitive function.