S-100蛋白的动态变化对急性出血性脑血管病评价的临床意义

目的：通过观察急性出血性脑血管病患者血浆中S-100蛋白的动态变化，分析其与脑出血相应临床变化之间的关系。方法：应用ELISA法对62例急性出血性脑血管病患者及36例对照的血浆S-100蛋白水平进行动态检测及比较；应用CT测定出血体积并用ICH评分对脑出血进行临床评价。结果：急性出血性脑血管病患者S-100蛋白浓度在发病早期明显升高，1～3d达到峰值，显著高于恢复期及对照组；对于ICH评分较高者S-100蛋白升高更明显，两者呈正相关（P〈0．05）。结论：S-100可作为急性出血性脑血管病损伤早期敏感的检测指标并对患者的预后评价具有重要的临床意义。

Clinical Significance of S-100 Protein Dynamic Change for ICH Score of Acute Hemorrhagic Cerebrovascular Disease

Objective:To investigate the relationship between serum S-100 protein in blood and hemorrhagic cerebrovascular disease(HCD).Methods:An ELISA assay was used to detect S-100 protein of 62 patients with HCD and 36 healthy controls,CT was used to measure the blood volume and ICH score was applied to the clinical evaluation after HCD.Results:The serum S-100 protein increased rapidly from the first day to the third day and decreased from the seventh day,also,the level of serum S-100 protein in the patients with HCD was significantly higher than that in controls.To the fifteenth day,the serum S-100 protein came back to a normal level.Conclusion:As a serum marker of focal brain damage after HCD,serum S-100 protein can play an important role in early diagnosis and the evaluation of prognosis of HCD.