| 膀胱癌患者Ⅱ型环氧合酶和血管内皮生长因子的表达及意义 |
| |
| 引用本文： | 沈军,夏宏辉,王开昕,方建民,谢磊,李文杰,虞晓勇,王可兵. 膀胱癌患者Ⅱ型环氧合酶和血管内皮生长因子的表达及意义[J]. 临床泌尿外科杂志, 2010, 25(4): 253-255. DOI: 10.3969/j.issn.1001-1420.2010.04.003 |
| |
| 作者姓名： | 沈军 夏宏辉 王开昕 方建民 谢磊 李文杰 虞晓勇 王可兵 |
| |
| 作者单位： | 1. 广东医学院附属南山医院泌尿外科,广东,深圳,518052
2. 广东医学院附属南山医院病理科 |
| |
| 摘 要： | 目的:探讨Ⅱ型环氧合酶(Cox-2)和血管内皮生长因子(VEGF)的表达与膀胱移行细胞癌(BTCC)生物学行为的关系。方法:应用免疫组化方法对139例BTCC以及36例正常膀胱组织中的Cox-2和VEGF进行检测。结果:Cox-2的阳性率在T_(a～1)和T_(2～4)分别为34.3%和75.0%(P0.001);Ⅰ级和Ⅲ级的表达率分别为33.9%和81.8%(P0.001)。VEGF的阳性表达率在T_(a～1)和T_(2～4)分别为23.9%和79.2%(P0.001);Ⅰ级和Ⅲ级的表达率分别为32.2%和84.8%(P0.001)。BTCC组织中COX-2与VEGF表达呈正相关(r=0.607,P0.05)。结论:Cox-2和VEGF可以作为了解BTCC生物学行为的有效指标。
|
| 关 键 词： | 膀胱移行细胞癌 环氧合酶 血管内皮生长因子 免疫组织化学 |
Expression of Cyclooxygenase2 and Vascular Endothelial Growth Factor in Bladder Transitional Cell Carcinoma |
| |
| Jun SHEN,Honghui XIA,Kaixin WANG,Jianmin FANG,Lei XIE,Wenjie LI,Xiaoyong YU,Kebing WANG. Expression of Cyclooxygenase2 and Vascular Endothelial Growth Factor in Bladder Transitional Cell Carcinoma[J]. Journal of Clinical Urology, 2010, 25(4): 253-255. DOI: 10.3969/j.issn.1001-1420.2010.04.003 |
| |
| Authors: | Jun SHEN Honghui XIA Kaixin WANG Jianmin FANG Lei XIE Wenjie LI Xiaoyong YU Kebing WANG |
| |
| Affiliation: | 1.Department of Urology, Lanshan affiliated Hospital of Guangdong Medical College, Shenzhen, Guangdong, 518052, China; 2.Department of Pathology, Clinical College of Guangdong Medical College) |
| |
| Abstract: | Objective：To study the relationship between the expression of Cox-2 and VEGF and the biological behavior of bladder transitional cell carcinoma. Methods：The expressions of Cox-2 and VEGF were studied by immunohistochemistry in 139 cases of bladder cancer , 36 cases of normal bladder tissue. Results：The positive rate of Cox-2 in different group were as follow ： T0-1 34.3% , T2-4 75.0% （P〈 0. 05）, the expression rate were Ⅰ 33.90/00, Ⅲ 81.8% （P〈0.05）. The positive rate of VEGF in different group were as follow： Ta-1 23.9% ,T2-4 79.2% （P〈0. 05） ,the expression rate were Ⅰ 32.2%, Ⅲ 84.8% （P〈0.05）. The expression of Cox-2 was posi- tively correlated with that of VEGF（ r= 0. 607, P〈0. 05）. Conclusions：The expression of Cox-2 and VEGF may be parameters for understanding the biological behavior of bladder transitional cell carcinoma. |
| |
| Keywords: | bladder transitional cell carcinoma Cox-2 VEGF immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
