Cardiovascular responses to graded doses of three catecholamines during lactic and hydrochloric acidosis in dogs |
| |
Authors: | HUANG, Y.-G. WONG, K. C. YIP, W.-H. McJAMES, S. W. PACE, N. L. |
| |
Affiliation: | Department of Anesthesiology, University of Utah School of Medicine Salt Lake City, UT 84132, USA. Peking Union Medical College Hospital Beijing, China Kaohsiung Medical College Hospital Taiwan |
| |
Abstract: | We have studied the cardiovascular effects of incremental dosesof three catecholamines in dogs subjected to lactic (LAC) andhydrochloric (HCl) acidosis. Fifty-four dogs were allocatedrandomly to one of three groups: control, LAC and HCl acidosis(n = 18 each group). In the acidotic models, 2 mol litre1of lactic acid (4 ml kg1 h1 or 2 mol litre1of HCl (1 ml kg1 h1) was infused i.v. until arterialpH was reduced to 7.00±0.1. Within each group, six dogsreceived one of three different drugs in logarithmically incrementaldoses: adrenaline 0.1, 0.2, 0.4, 0.8, 1.6, 3.2 µg kg1min1, noradrenaline 0.1, 0.2, 0.4, 0.8, 1.6, 3.2 µgkg1 min1 and dobutamine 5, 10, 20, 40, 80, 160µg kg1 min1 Cardiovascular variables weremonitored, with periodic measurements of plasma electrolyteand lactate concentrations. The pH reduction induced by HClor lactic acid was associated with a statistically significantincrease in mean pulmonary arterial pressure (MPAP), prominentespecially in the LAC group where MPAP increased from mean 18(SD 5) to 27 (6) mm Hg. In the acidotic models, the reductionin myocardial responsiveness to adrenaline or noradrenalinewas more prominent than that for the control for correspondingdoses of drugs. In the LAC group mean cardiac index decreasedsignificantly from 5.2 (1.8) to 2.2 (0.7) litre min1m2 after infusion of adrenaline 3.2 µg kg1min1 and decreased from 5.1 (1.1 to 2.4 (0.9) litre min1m1 after infusion of noradrenaline 3.2 µg kg1min1. In contrast, dobut amine showed dose-dependentincreases in cardiac index and heart rate in control, as wellas acidotic groups. The acute HCl acidosis induced greater hyperkalaemiathan the lactic acidosis. (Br. J. Anaesth. 1995; 74: 583590) |
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|