Transcytosis and catabolism of antibody |
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Authors: | Ghetie Victor Ward E Sally |
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Institution: | (1) Present address: Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX;(2) Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX |
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Abstract: | This review describes the evolution of our knowledge of the transmission of immunoglobulin G (IgG) from mother to infant and
the factors which regulate the persistence of IgG in the circulation. These apparently unrelated processes involve the same
Fc receptor, FcRn (n=neonatal). FcRn appears to carry out these diverse roles by binding to IgG and then either transporting
the bound IgG across cells (transcytosis) or recycling its cargo back to the cell surface (control of catabolism). IgG that
is taken up by cells in the absence of binding to FcRn undergoes degradation. Thus, FcRn is the “protective” receptor that
servesto maintain IgG homeostasis and deliver IgGs across cellular barriers. |
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Keywords: | Transcytosis Catabolism Antibody Immunoglobulin G Fc receptor Neonatal Fc receptor |
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