| 前列腺癌与良性前列腺增生差异表达基因的研究 |
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| 引用本文： | 张彤,徐勇,汤华,刘民,任大林,牛远杰. 前列腺癌与良性前列腺增生差异表达基因的研究[J]. 中华男科学杂志, 2004, 10(12): 897-899 |
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| 作者姓名： | 张彤 徐勇 汤华 刘民 任大林 牛远杰 |
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| 作者单位： | 1. 天津医科大学第二医院泌尿外科,天津,300211
2. 天津市生命科学中心实验室,天津,300070 |
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| 摘 要： | 目的 :筛选和分析前列腺癌 (PCa)与良性前列腺增生 (BPH)组织中差异表达的基因。 方法 :应用含有 4 6 5个基因的寡聚核苷酸芯片 ,检测PCa和BPH组织中差异表达的基因。 结果 :PCa和BPH组织中表达差异有显著性的基因共 35个 ,PCa上调基因 1 7个 ,下调 1 8个。 结论 :PCa与BPH组织差异表达基因的研究 ,有助于了解PCa发生发展的分子机制和寻找PCa新的诊断治疗标志物。
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| 关 键 词： | 前列腺癌 良性前列腺增生 基因 基因芯片 |
| 文章编号： | 1009-3591(2004)12-0897-03 |
| 修稿时间： | 2004-04-25 |
Differentially Expressed Genes in Prostate Cancer and Benign Prostatic Hyperplasia |
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| Zhang Tong,Xu Yong,Tang Hua,Liu Min,Ren Dalin,Niu Yuanjie. Differentially Expressed Genes in Prostate Cancer and Benign Prostatic Hyperplasia[J]. National journal of andrology, 2004, 10(12): 897-899 |
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| Authors: | Zhang Tong Xu Yong Tang Hua Liu Min Ren Dalin Niu Yuanjie |
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| Affiliation: | Department of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. |
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| Abstract: | Objective: To detect and analyze the differentially expressed genes in prostate cancer(PCa)and benign prostatic hyperplasia(BPH). Methods: Oligonucleotide microarray containing 465 genes was used to investigate the differentially expressed genes in PCa and BPH. Results: There were 35 differentially expressed genes between PCa and BPH, of which 17 were up-regulated and 18 down-regulated in PCa. Conclusion: The study of the differentially expressed genes in PCa and BPH should help to understand the molecular mechanism of PCa and identify the markers for diagnostic and therapeutic use. |
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| Keywords: | prostate cancer benign prostatic hyperplasia gene gene microarray |
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