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Genetic control of drug resistance: Assignment ofama-1 to Chinese hamster chromosome 7, confirmation of assignment of genes coding for TK,GALK, and ACP to chromosome 7, and tentative assignment of TPI to chromosome 8 |
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| Authors: | Michele Roberts George A. Scangos John T. Hart Frank H. Ruddle |
| Affiliation: | 1. Department of Human Genetics, Yale University, 06511, New Haven, Connecticut 2. Department of Biology, Johns Hopkins University, 21218, Baltimore, Maryland 3. Department of Biology, Yale University, 06511, New Haven, Connecticut |
| Abstract: | The gene which specifies a subunit of RNA polymerase II, ama-1,is assigned to chromosome 7 in the Chinese hamster. The assignment of genes coding for TK, GALK, and ACP to chromosome 7 is confirmed, with a provisional regional assignment of TK and GALK to 7q. On the basis of one clone with six subclones, a provisional assignment of TPI to Chinese hamster chromosome 8 is made. With the assignment of tkand ama-1to chromosome 7 in the CHO cell line Amal, this chromosome is shown to have two selectable markers. |
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