| 血栓闭塞性脉管炎患者血栓素、前列环素及血液流变学指标的检测分析 |
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| 引用本文： | 张淑兰,魏晨玲.血栓闭塞性脉管炎患者血栓素、前列环素及血液流变学指标的检测分析[J].微循环学杂志,2005,15(1):58-59. |
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| 作者姓名： | 张淑兰 魏晨玲 |
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| 作者单位： | 石家庄市中医院检验科,石家庄,050051 |
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| 摘 要： | 目的 :探讨血栓闭塞性脉管炎患者血栓素B2 、前列环素与血液流变学指标的变化及其与发病机制的关系。方法 :用放射免疫法测定TXA2 和PGI2 的代谢产物血栓素B2 (TXB2 )、6 酮 前列腺素F1α( 6 K PGF1α) ,LBY N6A自清洗旋转式粘度计测定血液流变学指标 ,并与对照组对比分析。结果 :血栓闭塞性脉管炎患者TXB2 ( 53.59± 83.2 1ng/L)、6 K PGF1α( 14 .50± 3.4 5ng/L) ,与对照组相比差异显著 ;全血高切粘度、低切粘度、血浆粘度及纤维蛋白原疾病组均高于对照组 ,差异具有统计学意义。结论 :血栓闭塞性脉管炎患者存在TXA2 /PGI2失衡 ,并与血液流变学的改变有密切关系
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| 关 键 词： | 血栓闭塞性脉管炎 血栓素B2 6酮前列腺素F1α 血液流变学 |
| 文章编号： | 1005-1740(2005)01-0058-02 |
| 修稿时间： | 2004年8月6日 |
Detective Analysis on Plasma TXB2,PGI2 and Indieation of Hemorheology in Patients with Thromboangitis Obliterans |
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| Zhang Shulan,Wei Chenling./.Detective Analysis on Plasma TXB2,PGI2 and Indieation of Hemorheology in Patients with Thromboangitis Obliterans[J].Chinese Journal of Microcirculation,2005,15(1):58-59. |
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| Authors: | Zhang Shulan Wei Chenling/ |
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| Institution: | Zhang Shulan,Wei Chenling./Department of Laboratory,Shijiazhuang hospital of Tradational Chinese M edicine,Shijiazhuang 050051 |
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| Abstract: | Objective:To investigate the relationship between pathogenesis of thromboangitis obliterans(TAO) and change of hemorhelogy.Method:TXB 2 and PGI 2 were analyzed by radioimmunoassay,The le vels of hemorhelogy were analyzed by LBY-N6A viscometer in TAO and healthy co ntrols. Results:Plasma levels of TXB 2 and 6-K-PGF1α were significa ntly higher in patients with TAO than those in controls.The expression of blood viscosity changes were significantly higher in patients than those in control.Conclusion:TXA 2/PGI 2 of TAO is imbalance,and the imbalance may relate to the change of hemorhelogy. |
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| Keywords: | Thromboangitis obliterans TXB 2 6-K-PGF 1α Hemorrheology▲CHINESE JOURNAL OF MICROCIRCULATION·Vol 15 No 1[BHDWG10mm WK50mm WK120mmYQ3*4/5W]PAGE· 4 ABSTRACTS OF ORIGINAL ARTICLES |
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