| ATP敏感性钾通道与缺血性脑损伤研究进展 |
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| 引用本文： | 李捷萌,陈彦青,刘荣国. ATP敏感性钾通道与缺血性脑损伤研究进展[J]. 医学综述, 2008, 14(7): 964-966 |
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| 作者姓名： | 李捷萌 陈彦青 刘荣国 |
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| 作者单位： | 福建医科大学省立临床学院麻醉科,福州,350001 |
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| 摘 要： | 缺血性脑损伤的发生机制目前尚未明确,临床缺乏有效的治疗手段。对ATP敏感性钾通道的研究主要集中于各种组织的缺血及预适应或缺血再灌注的细胞保护方面。研究发现,ATP敏感性钾通道在缺血性脑损伤的病理生理过程中具有重要的作用。本文对该通道的分子结构、在神经系统内的分布、调控机制、相关药物的作用机制和药理学原理、以及其在缺血性脑损伤中的作用机制进行详细的介绍。
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| 关 键 词： | ATP敏感钾通道 脑缺血 调节机制 作用机制 |
| 文章编号： | 1006-2084(2008)07-0964-03 |
| 修稿时间： | 2007-10-14 |
Research Development of ATP-sensitive K~+ Channels and Ischemic Brain Injury |
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| LI Jie-meng,CHEN Yan-qing,LIU Rong-guo. Research Development of ATP-sensitive K~+ Channels and Ischemic Brain Injury[J]. Medical Recapitulate, 2008, 14(7): 964-966 |
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| Authors: | LI Jie-meng CHEN Yan-qing LIU Rong-guo |
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| Affiliation: | LI Jie-meng,CHEN Yan-qing,LIU Rong-guo.(Department of Anaesthesiology,Provincial Clinical Hospital,Fujian Medical University,Fuzhou 350001,China) |
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| Abstract: | The mechanism of ischemic brain injury has not been elucidated thoroughly now,and there is no effective therapy in clinic.The research about ATP-sensitive K+ channels is mainly focused on the cytoprotection of tissue ischemia and preadaptation or tissue ischemia-reperfusion.Studies showed that ATP-sensitive K+ channels play an important role in the pathophysiological processes of ischemic cerebral injury.This article reviews this chaannel about its molecular structure,distribution in the nervous system,regu... |
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| Keywords: | ATP-sensitive K~+ channels Cerebral ischemia Regulatory mechanism Mechanism of action |
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