Decreased atropine toxicity in rats chronically exposed to cold |
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| Authors: | S C Kalser D Evans E Forbes M Kelly E Kelvington R Kunig M Randolph |
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| Affiliation: | 1. Univ. Lille, EA 7365 – GRITA - Groupe de Recherche sur les formes Injectables et les Technologies Associées, F-59000 Lille, France;2. CHU Lille, Pôle anesthésie-réanimation, maternité Jeanne de Flandre, F-59000 Lille, France;3. CHU Lille, Unité fonctionnelle de toxicologie, centre biologie pathologie, F-59000 Lille, France;4. Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, F-59000 Lille, France;5. CHU Lille, Centre des Brûlés, F-59000 Lille, France;6. CHU Lille, Pôle anesthésie-réanimation, hôpital Huriez, F-59000, Lille, France |
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| Abstract: | Environmental conditioning to cold has been shown to alter the toxicity of atropine sulfate in rats when it is administered by an intraperitoneal, but not by an intravenous route. Rats exposed to 5°C for 49 days tolerate twice the amount of atropine sulfate tolerated by rats exposed to 5° for only 1 day. This tolerance parallels the slower absorption of the drug from the peritoneal cavity compared with the absorption rates for acutely cold-exposed rats, or rats maintained at 25°. Although excretion of drug into the urine and bile is not higher for the chronic cold animal, its tissue concentrations are somewhat lower. This suggests that the cold-acclimated rat decreases the toxicity of atropine by limiting absorption rather than by increasing excretion. |
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