Transfer of bromocriptine across the blood-brain barrier in man

The transfer of ¹⁴C-bromocriptine across the blood-brain barrier was studied in 10 patients using the double indicator single injection method. The extraction (E) of bromocriptine was 8 % (quartiles: 6 and 14 %). Based on the results the cerebral uptake velocity of bromocriptine was calculated assuming constant arterial drug concentration. Its T_1/2 was found to be 12–24 minutes, depending on the tissue-blood partition coefficient.