| 可注射硅溶胶-抗生素假体在感染的兔人工髋关节一期翻修中的作用 |
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| 引用本文： | 韩庚奋,王爱民,熊雁,龚滨,王子明.可注射硅溶胶-抗生素假体在感染的兔人工髋关节一期翻修中的作用[J].第三军医大学学报,2010,32(19). |
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| 作者姓名： | 韩庚奋 王爱民 熊雁 龚滨 王子明 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所骨科,重庆,400042 |
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| 摘 要： | 目的 探讨可注射硅溶胶-抗生素假体在感染的兔人工髋关节一期翻修中的作用.方法 选取28只新西兰大白兔,制作人工关节术后金黄色葡萄球菌感染模型,采用完全随机分组法将其分为对照组(n=14)和实验组(n=14).对照组采用普通型兔人工假体,实验组采用可注射硅溶胶-抗生素假体对感染模型进行一期翻修.术后12周处死动物,激光扫描共聚焦显微镜(CLSM)检测假体周围生物膜,并计算生物膜突破成功率.扫描电镜(SEM)观察假体表面生物膜.取假体周围组织行组织学观察,最后细菌培养检测翻修成功率. 结果 CLSM检测生物膜突破成功率:实验组85.7%(12/14),对照组35.7%(5/14),二者差异有统计学意义(P<0.05).SEM观察:实验组未见明显的金黄色葡萄球菌,但细菌分泌的基质仍然可见;对照组可见大量金黄色葡萄球菌被其分泌的基质包裹在一起.组织学观察:实验组可见纤维细胞增生,炎性细胞明显比对照组少.细菌培养:实验组翻修成功率85.7%(12/14),对照组翻修成功率42.9%(6/14),二者差异有统计学意义(P<0.05).结论 可注射硅溶胶-抗生素假体能抑制和突破假体周围生物膜,显著提高一期人工髋关节翻修成功率.
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| 关 键 词： | 可注射硅溶胶-抗生素 人工髋关节 一期翻修 生物膜 感染 |
Role of injectable silica sol-gel/antibiotics prosthesis in phase 1 revision arthroplasty for infected prosthetic hip joints of rabbits |
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| Han Gengfen,Wang Aimin,Xiong Yan,Gong Bin,Wang Ziming.Role of injectable silica sol-gel/antibiotics prosthesis in phase 1 revision arthroplasty for infected prosthetic hip joints of rabbits[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(19). |
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| Authors: | Han Gengfen Wang Aimin Xiong Yan Gong Bin Wang Ziming |
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| Institution: | Han Gengfen,Wang Aimin,Xiong Yan,Gong Bin,Wang Ziming(Department of Orthopedics,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing,400042,China) |
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| Abstract: | Objective To study the role of injectable silica sol-gel/antibiotics prosthesis in phase 1 revision arthroplasty for infected prosthetic hip joints of rabbits.Methods Twenty-eight New Zealand white rabbits were used in this study.A Staphylococcus aureus infection model was established after arthroplasty.The rabbits were randomly divided into control group and experimental group,14 in each group.Rabbits in control group underwent arthroplasty using common prosthesis and those in experimental group received a... |
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| Keywords: | injectable silica sol-gel/antibiotics prosthetic hip joint phase 1 revision arthroplasty biofilm infection |
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