| 组织因子和组织因子途径抑制物与动脉粥样斑块形成关系的研究进展 |
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| 引用本文： | 朱颖,罗心平,马端. 组织因子和组织因子途径抑制物与动脉粥样斑块形成关系的研究进展[J]. 心血管病学进展, 2007, 28(5): 759-762 |
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| 作者姓名： | 朱颖 罗心平 马端 |
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| 作者单位： | 1. 复旦大学附属华山医院心内科,上海,200040
2. 复旦大学分子医学教育部重点实验室,上海,200032 |
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| 摘 要： | 动脉粥样硬化的发生与局部血栓形成密切相关,已知组织因子(tissue factor,TF)是血栓形成的起始因子,组织因子途径抑制物(tissue factor pathway inhibitor,TFPI)是TF的生理抑制剂,它有两种同族异形体,TFPI-1和TFPI-2。TFPI-1在抑制血栓形成和血管重塑等方面发挥重要作用;TFPI-2则可能与动脉粥样斑块的稳定性有关。近年来TF和TFPI在动脉粥样硬化发生和发展过程中的作用得到广泛关注,现就此方面的研究进展综述如下。
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| 关 键 词： | 组织因子 组织因子途径抑制物-1 组织因子途径抑制物-2 动脉粥样斑块 |
| 文章编号： | 1004-3934（2007）05-0759-04 |
| 修稿时间： | 2006-11-022007-01-16 |
Tissue Factor and Tissue Factor Pathway Inhibitor in Coronary Atherosclerotic Plaque |
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| ZHU Ying,LUO Xin-ping,MA Duan. Tissue Factor and Tissue Factor Pathway Inhibitor in Coronary Atherosclerotic Plaque[J]. Advances in Cardiovascular Diseases, 2007, 28(5): 759-762 |
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| Authors: | ZHU Ying LUO Xin-ping MA Duan |
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| Affiliation: | 1. Department of Cardiology, The Huashan Hospital of Fudan University, Shanghai 200040, China; 2, The Key Laboratory of Molecular Medicine, Ministry of Education, Fudan University, Shanghai 200032, China |
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| Abstract: | Tissue factor(TF) is a receptor for factor FVII/FVIIa on a cell surface.It is an important initiator of the exdogenous coagulation cascade,and TF activates exdogenous coagulation cascade and causes thrombosis.Human tissue factor pathway inhibitor(TFPI) is a member of the Kunitz-type serine protease inhibitor family,which is divided into TFPI-1 and TFPI-2.The key function of TFPI-1 is anti-coagulation,while TFPI-2 as a broad-spectrum serine protease inhibitor can function as an MMP inhibitor.The differences between TFPI-1 and TFPI-2 lead to discrepancies in the roles they play in a variety of pathological processes in coronary atherosclerotic plaque.This article reviews recent progress in the related research. |
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| Keywords: | tissue factor tissue factor pathway inhibitor-1 tissue factor pathway inhibitor-2 coronary atherosclerotic plaque |
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