| 紫杉醇类衍生物的定量结构-抗癌活性关系研究进展 |
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| 引用本文： | 李燕,王永华,房华,李兰婷,张述伟. 紫杉醇类衍生物的定量结构-抗癌活性关系研究进展[J]. 中国药理学通报, 2008, 24(3): 288-293 |
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| 作者姓名： | 李燕 王永华 房华 李兰婷 张述伟 |
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| 作者单位： | 1. 大连理工大学材料化工系,辽宁,大连,116012
2. 大连水产学院生命科学与技术学院,辽宁,大连,116023 |
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| 基金项目： | 大连理工大学校科研和教改项目 , 大连理工大学博士科研启动基金 |
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| 摘 要： | 该文就目前以分子模拟为手段的紫杉醇类分子的定量结构-抗癌活性关系研究进行了综述。主要围绕该类分子结构的关键活性基团,即C13侧链、C14、C2、C10位基团及四元氧环对活性的贡献进行论述,总结了目前此类研究达成的共识及争议。此外,对结构之外的其他活性影响因素及活性分类研究也进行了汇总。
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| 关 键 词： | 紫杉醇 紫杉烷 分子模拟 定量构效关系 |
| 文章编号： | 1001-1978（2008）03-0288-06 |
| 收稿时间： | 2008-01-05 |
| 修稿时间： | 2008-02-16 |
Research progress in the quantitative structure-antitumor activity relationship studies of taxol derivatives |
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| LI Yan,WANG Yong-hua,FANG Hua,LI Lan-ting,ZHANG Shu-wei. Research progress in the quantitative structure-antitumor activity relationship studies of taxol derivatives[J]. Chinese Pharmacological Bulletin, 2008, 24(3): 288-293 |
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| Authors: | LI Yan WANG Yong-hua FANG Hua LI Lan-ting ZHANG Shu-wei |
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| Abstract: | The up-to-date quantitative structure-antitumor activity relationship studies of taxol analogues based on molecular model- ing techniques were reviewed in the present paper. Both the common understandings and the debates about the contributions of several key structural groups, including the C13 side chain, the substituents of C14, C2 and CIO as well as the oxtane ring to the biological activities of taxol derivatives were summerized. In addition, the studies about other factors influencing the activity except for the structure and the classification research of the mol- ecules were also discussed. |
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| Keywords: | taxol taxoid molecular modeling QSAR |
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