人参皂苷联合地塞米松防治经动脉化疗栓塞术后肝肾功能损伤的前瞻性研究

目的评价人参皂苷（GS）联合小剂量地塞米松（Dex）对原发性肝癌患者经动脉化疗栓塞术（TACE）后肝。肾功能损害的防治效果。方法采用前瞻性随机对照研究方法,将120例原发性肝癌患者随机分为安慰剂组、Dex组、GS组、GS＋Dex组,每组30例。参照世界卫生组织（WHO）抗肿瘤药物毒副反应分度标准,观察各组患者TACE术前第3天和术后第3、7天肝。肾功能的变化。结果与安慰剂组比较,GS＋Dex组对总胆红素、谷丙转氨酶／谷草转氨酶、尿素氮及Child-Pugh分级有明显减低作用,TACE术后第3天组间比较,差异均具有统计学意义（P均〈0．05）。GS和Dex单药对肝。肾功能部分指标虽然也有一定保护作用,但从全面保护肝肾功能的角度看,其效果明显不如联合用药。结论GS联合小剂量Dex可有效防治原发性肝癌患者TACE术后的肝。肾功能损伤。

Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient

OBJECTIVE: To observe the protective effect of ginsenosides (GS) or low dose of glucocorticoid dexamethasone (Dex) alone or combined in managing the liver injury and renal function after transcatheter arterial chemoembolization (TACE). METHODS: 120 patients with primary liver carcinoma were randomly divided into four groups (A, B, C, D) with 30 patients in each. Group A was treated with placebo; group B with Dex; group C with GS and group D with Dex plus GS. The changes in liver and renal function after TACE were observe according to the WHO criteria for side effects of anti-cancer drug. RESULTS: Compared with group A, Dex combined with GS was able to reduce the level of TB, ALT/AST, BUN and Child-grade, which significantly protected the liver and kidney (P < 0. 05). However, Dex or GS alone could also improve some parameters of liver and renal function after TACE (P < 0.05). CONCLUSION: Dex combined with GS is effective in managing the liver injury and renal function after transcatheter arterial