Zona pellucida thickness variation and occurrence of visible mononucleated blastomeres in preembryos are associated with a high pregnancy rate in IVF treatment |
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Authors: | Måns Palmstierna Daniel Murkes György Csemiczky Ola Andersson Håkan Wramsby |
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Institution: | (1) Department of Woman and Child Health, Division of Obstetrics & Gynaecology, Karolinska Hospital, P.O. Box 140, S-171 76 Stockholm, Sweden;(2) Department of Psychology, University of Stockholm, Stockholm, Sweden |
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Abstract: | Purpose: The ability of six morphological criteria (embryo development rate, fragmentation, regularity of blastomere shape, equality
of blastomere size, zona pellucida thickness variation ZPTV], and visible mononucleated blastomeres VMBs]) to predict pregnancy
in IVF treatment cycles was evaluated.
Methods: In order to select a homogeneous study group, 85 consecutive nulliparous couples with single tubal infertility undergoing
their first IVF treatment and receiving three preembryos at embryo replacement 2 days after ovum pickup were included.
Results: A total of 255 preembryos was replaced two days after ovum pickup and resulted in 34 clinical pregnancies (40%). By logistic
regression analysis, ZPTV and VMBs showed highly significant and strong predictive values, whereas none of the other parameters
was a significant predictor of pregnancy. In the treatments in which all replaced preembryos had a ZPTV of less than 15%,
the pregnancy rate was extremely low (1/22). If the maximum ZPTV of any of the replaced preembryos was in the interval between
15 and 20%, the pregnancy rate was 24.1% (7/29). In the treatments in which at least one preembryo had a ZPTV of more than
20%, the pregnancy rate was 76.5% (26/34). When VMBs were added to the results of the ZPTV analysis, the pregnancy rate was
as high as 92.3% (24/26).
Conclusions: ZPTV and VMBs seem to be strong predictors of pregnancy in IVF treatment and thus important indicators of good embryo quality. |
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Keywords: | in vitro fertilization preembryo zona Pellucida blastomere pregnancy |
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