| 红毛五加多糖对胃癌细胞的诱导凋亡作用 |
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| 引用本文： | 吕晓英,刘新华,李由,郑保春,李建明,王双印,曾令福. 红毛五加多糖对胃癌细胞的诱导凋亡作用[J]. 中国癌症杂志, 2001, 11(2): 137-139,142 |
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| 作者姓名： | 吕晓英 刘新华 李由 郑保春 李建明 王双印 曾令福 |
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| 作者单位： | 1. 成都军区联勤部军事医学研究所一室,
2. 华西医科大学公共卫生学院, |
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| 摘 要： | 目的：研究红毛五加多糖对胃癌的诱导凋亡作用及其作用机制。方法：采用流式细胞术检测凋亡细胞百分比及基因和细胞因子蛋白含量。结果：该多糖使癌基因bcl-2蛋白表达降低，而使抑癌基因p53、bax、Fas、Fas-L及细胞因子TGFβ1蛋白表达增高。结论：该多糖通过降低原癌基因蛋白表达，增高抑癌基因和细胞因子蛋白表达，从而诱导胃癌细胞SGC-7901凋亡。
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| 关 键 词： | 红毛五加多糖 胃癌 细胞凋亡 基因表达 细胞因子 AGP |
| 文章编号： | 1007-3639(2001)02-0137-03 |
Inducing apoptosis effectsof acanthopanax giraldii polysacchrides on the human gastric cancer cell |
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| LU Xiao-ying,LIU Xin-hua,LI You,et al. Inducing apoptosis effectsof acanthopanax giraldii polysacchrides on the human gastric cancer cell[J]. China Oncology, 2001, 11(2): 137-139,142 |
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| Authors: | LU Xiao-ying LIU Xin-hua LI You et al |
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| Abstract: | Purpose：To investigate the inducing apoptosis effects and their mechanisms of Acanthopanax giraldii harms Var Hispidus Hoo polysaccharides(AGP) on the gastric cancer. Methods：Flow cytometry was adopted to detect the percentage of apoptosis cells and the expression of gene and cell factor. Results：The gastric caner cell apoptosis was induced and the protein expression of cancer gene bcl-2 was low, while that of p53、bax、Fas、Fas-L genes and cell factor TGFβ1 were high after cultured with AGP. Conclusions：The cell apoptosis was induced by high expression of antioncogenes，cell factor and low expression of oncogene after gastric cancer cell line SGC-7901 was treated with AGP. |
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| Keywords: | acanthopanax giraldii polysaccharides apoptosis gastric cancer gene cell factor |
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