Classical conditioning of amphetamine-induced lateralized and nonlateralized activity in rats |
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Authors: | K. L. Drew S. D. Glick |
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Affiliation: | (1) Department of Pharmacology and Toxicology, Albany Medical College, 47 New Scotland Avenue, 12208 Albany, NY, USA |
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Abstract: | Amphetamine-induced lateralized activity (rotation) and nonlateralized activity (extra quarter turns) was classically conditioned in female rats using the test environment as the conditioned stimulus (CS) and 1.25 mg/kg d-amphetamine as the unconditioned stimulus. Conditioned lateralized activity extinguished more rapidly than nonlateralized activity. Also, d-amphetamine-induced nonlateralized activity was selectively decreased by a schedule of 50% partial reinforcement. These results indicate that the two d-amphetamine responses can be distinguished, that they are differentially affected by learning, and that a schedule of partial reinforcement can selectively attenuate one effect of a drug while leaving the other intact. In addition, haloperidol blocked conditioned lateralized activity; this suggests that the conditioned response may be, like the drug-induced response, mediated by dopamine. |
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Keywords: | Rotational behavior Lateralized activity Amphetamine Classical conditioning Partial reinforcement Haloperidol |
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