|
|||||
|
|
Time-dependent effects of low-level laser therapy on the morphology and oxidative response in the skin wound healing in rats |
|
| Authors: | Reggiani Vilela Gonçalves Rômulo Dias Novaes Marli do Carmo Cupertino Bruna Moraes João Paulo Viana Leite Maria do Carmo Gouveia Peluzio Marcus Vinicius de Mello Pinto Sérgio Luis Pinto da Matta |
| Affiliation: | 1. Department of Morphology, Federal University of Pelotas, Pelotas, RS, Brazil 2. Department of General Biology, Edifício Shotaro Shymoia, Federal University of Vi?osa, Avenida PH Rolfs, s/no, CEP: 35.570-000, Vi?osa, MG, Brazil 3. Department of Animal Biology, Federal University of Vi?osa, Vi?osa, MG, Brazil 4. Department of Biochemistry and Molecular Biology, Federal University of Vi?osa, Vi?osa, MG, Brazil 5. Department of Nutrition and Health, Federal University of Vi?osa, Vi?osa, MG, Brazil 6. Department of Laser and Pain, University of Caratinga, Caratinga, MG, Brazil |
| Abstract: | This study aims to investigate the effect of different energy densities provided by low-level laser therapy (LLLT) on the morphology of scar tissue and the oxidative response in the healing of secondary intention skin wounds in rats. Twenty-four male adult Wistar rats were used. Skin wounds were made on the backs of the animals, which were randomized into three groups of eight animals each as follows, 0.9% saline (control); laser GaAsAl 30 J/cm2 (L30); laser GaAsAl 90 J/cm2 (L90). The experiment lasted 21 days. Every 7 days, the wound contraction index (WCI) was calculated and tissue from different wounds was removed to assess the proportion of cells and blood vessels, collagen maturation index (CMI), thiobarbituric acid reactive substance (TBARS) levels and catalase activity (CAT). On the 7th and 14th days, the WCI and the proportion of cells were significantly higher in groups L30 and L90 compared to the control (p?p?p? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |