Differential behavioral effects of ACTH 4–10 and [D-Phe7]ACTH 4–10 |
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| Authors: | V.M. Wiegant D. Colbern Tj.B. Van Wimersma Greidanus W.H. Gispen |
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| Affiliation: | Department of Psychology, University of Florida, Gainesville, FLUSA;Division of Molecular Neurobiology Rudolf Magnus Institute for Pharmacology and Laboratory of Physiological Chemistry Medical Faculty, Institute of Molecular Biology, University of Utrecht, The Netherlands |
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| Abstract: | Intraventricular administration of an access of ACTH 4–10 does not interfere with the excessive grooming behavior of rats, elicited by intraventricular administration of [D-Phe7 ]ACTH 4–10. In an avoidance extinction paradigm, the two ACTH analogs have opposite effects. ACTH 4–10 counteracts the facilitation of extinction seen after [D-Phe7]ACTH 4–10, only under conditions that treatment with ACTH 4–10 alone results in retardation of that extinction. The data are discussed in terms of a multiple interaction of these peptides with brain function. |
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| Keywords: | Grooming Avoidance-extinction ACTH 4–10 Neuropeptides |
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