Induction of artificial endometrial cycles with oestradiol implants and injectable progesterone: establishment of a viable pregnancy in a woman with 17-a-hydroxylase deficiency |
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| Authors: | Ben-Nun, Isaac Siegal, Annette Shulman, Adrian Ghetler, Yehudith Kaneti, Hagai Lunenfeld, Bruno Beyth, Yoram Fejgin, Moshe |
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| Affiliation: | 2Departments of Obstetrics and Gynecology, Fertility Clinic and In Vitro Fertilization Unit Kfar Saba 3Departments of Pathology, Sapir Medical Center Kfar Saba 4Department of Endocrinology, Sheba Medical Center, Tel Hashomer (affiliated to Sackler Faculty of Medicine, Tel Aviv University Israel |
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| Abstract: | Repeated attempts with oral oestrogens and injectable progesteronefailed to induce secretory endometrium in a woman with 17- -hydroxylasedeficiency. The insertion of s.c. 17- -oestradiol implants dramaticallyimproved the endometrial response and enabled the establishmentof endometrial maturation. A viable pregnancy was achieved afterthe uterine transfer of in-vitro fertilized donated eggs. |
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| Keywords: | endometrial maturation/17-![]("</a) /math/alpha.gif" ALT=" {alpha}" BORDER=" 0" >-hydroxylase deficiency/17- /math/beta.gif" ALT=" {beta}" BORDER=" 0" >-oestradiol implants/viable pregnancy |
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