斜视性弱视伴偏中心注视眼的多焦视网膜电图表现

目的：探究斜视性弱视伴偏中心注视眼的多焦视网膜电图(mfERG)特征性变化。

方法：收集2018-01/2020-12在我院就诊的斜视性弱视伴偏中心注视患者20例作为研究组(4例为外斜视，16例为内斜视)，同时收集屈光不正性弱视患者20例作为对照组。散瞳状态下检查mfERG，记录P1波的振幅密度和潜伏期。

结果：斜视组弱视眼多焦视网膜电图P1波振幅密度与対侧眼相比第一环(P=0.001)，第二环(P<0.001)，第三环(P=0.001)，第四环(P=0.009)，第五环(P=0.026)明显降低； 与对照组相比第一环(P=0.033)，第二环(P=0.002)，第三环(P<0.001)，第四环(P=0.014)明显降低； 斜视组弱视眼潜伏期与対侧眼相比第一环(P=0.017)、第二环(P=0.001)有明显缩短，与对照组相比第二环(P=0.007)明显缩短。

结论：斜视性弱视伴偏中心注视眼的多焦视网膜电图P1波振幅密度越靠近黄斑中心凹下降越多，且与屈光不正性弱视眼相比下降更多。

Multifocal electroretinogram manifestation of strabismic amblyopia with eccentric central fixation

AIM: To explore the characteristic changes of multifocal electroretinogram(mfERG)in strabismic amblyopia eyes with eccentric fixation.

METHODS: A total of 20 patients with strabismus amblyopia and eccentric fixation visited our hospital from January 2018 to December 2020 were collected as the study group(4 patients with exotropia and 16 patients with esotropia), while 20 patients with ametropic amblyopia were collected as the control group. The mfERG was examined under the state of mydriasis, and the amplitude density and incubation period of P1 wave were recorded.

RESULTS: Compared with the fellow eyes, the first ring(P=0.001), the second ring(P<0.001), the third ring(P=0.001), the fourth ring(P=0.009)and the fifth ring(P=0.026)of strabismus amblyopia eyes were reduced significantly. Compared with the control group, the first ring(P=0.033), the second ring(P=0.002), the third ring(P<0.001)and the fourth ring(P=0.014)of strabismus amblyopia eyes were reduced significantly. The incubation period of amblyopia eyes in the strabismus group showed significantly shortened in the first ring(P=0.017)and the second ring(P=0.001)compared with the fellow eyes, and in the second ring(P=0.007)compared with the control group.

CONCLUSION: The amplitude density of mfERG P1 wave in strabismic amblyopia eyes with eccentric fixation reduced more with the closer to macular fovea, and reduced more significantly than that in the ametropic amblyopia eyes.