| 原发性高血压患者血浆内皮素、一氧化氮和D-二聚体的检测及临床意义分析 |
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| 引用本文： | 杨驭媒,毛元英,杨红英.原发性高血压患者血浆内皮素、一氧化氮和D-二聚体的检测及临床意义分析[J].中国分子心脏病学杂志,2008,8(5):286-288. |
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| 作者姓名： | 杨驭媒 毛元英 杨红英 |
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| 作者单位： | 四川省成都市第六人民医院检验科,610041 |
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| 摘 要： | 目的检测原发性高血压（essentialhypertension，EH）患者血浆内皮素（ET-1）、一氧化氮（NO）和D-二聚体（DD）的水平变化及分析其临床意义。方法选取94例原发性高血压患者作为研究对象，以62例健康人作为正常对照。分别采用放射免疫法测定血浆内皮素水平，硝酸还原酶法测定血浆一氧化氮水平和散射免疫比浊法测定D-二聚体水平，并进行统计学分析。结果与正常对照相比较，原发性高血压患者血浆ET-1和DD水平明显升高（P〈0．01），而NO水平则降低（P〈0．01）；经过治疗之后患者血浆ET-1和DD水平降低（P〈0．01），而NO水平升高（P〈0．01）。结论血浆ET-1、NO和DD联合检测，能够较好地反映原发性高血压患者的病情及进展，为其早期治疗和预测发展趋势提供重要依据。
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| 关 键 词： | 原发性高血压 内皮素 一氧化氮 D-二聚体 |
A study on plasma ET, NO and DD level of essential hypertension (EH) patients |
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| YANG Yu-mei,MAO Yuan-ying,YANG Hong-ying.A study on plasma ET, NO and DD level of essential hypertension (EH) patients[J].Molecular Cardiology of China,2008,8(5):286-288. |
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| Authors: | YANG Yu-mei MAO Yuan-ying YANG Hong-ying |
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| Institution: | ( Clinical Laboratory, The Sixth Hospital of Chengdu, Chengdu 610041, China) |
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| Abstract: | Objective To investigate the concentration of plasma ET-1,NO and DD in essential hypertension(EH)patients and controls.Methods In our study,plasma ET-1,NO and DD level was measured by radioimmunity,nitrate reductase assay,and nephelometric immunoassay,respectively.Results Plasma level of ET-1 and DD in EH group was higher than that in control group(P<0.01),and NO level in EH group was lower than that in control group(P<0.01).The level of ET-1 and DD in EH patients has fallen off(P<0.01)and NO level has increased(P<0.01)after therapy.Conclusion Significant differ- ence in plasma ET-1,NO and DD level was observed between EH group and control group,and it may play a very important role in the development of hypertension. |
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| Keywords: | Essential hypertension(EH) ET-1 NO DD |
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