调节性T细胞的变化对重型再生障碍性贫血临床转归的意义

目的了解调节性T细胞(Tregs)在再生障碍性贫血患者中的表达水平在疾病过程中的变化规律,探讨Tregs在再生障碍性贫血发病机制中的作用及其作为疾病预后和疗效判断指标的可能性。方法以流式细胞术方法检测21例重型再生障碍性贫血患者外周血单个核细胞中Tregs水平在经免疫抑制剂治疗前后的变化,并与正常对照组相比较。结果重型再障患者Tregs数量较正常人明显减少,而治疗有效者Tregs水平与正常人无差异,无效者Tregs无明显变化。结论 Tregs可能对维持正常的造血至关重要,Tregs的减少同再障的发生密切相关,并可以作为监测再障疗效的指标。

THE CLINICAL SIGNIFICANCE OF REGULATORY T CELLS TO THE PROGNOSIS OF SEVERE APLASTIC ANEMIA

Objective To investigate the expression level of regulatory T cells （Tregs） in aplastic anemia patients and its changing in the evolution of the disease, and to explore the rule of Tregs on the pathogenesis of apa- lastie anemia and the possibility of Tregs as the indicator of prognosis and the effect of treatment. Methods Tregs of peripheral blood mononuclear cells were analyzed before and after immunocompressive therapy in 21 patients with se- vere aplastic anemia by FACS, and, compared with normal control. Results The quantities of Tregs of severe aplas- tic anemia reduced dramatically compared with normal healthy, and recovered after effective therapy; non response patients remained the level of Tregs unchanged. Conclusion Tregs may play an important role in maintaining normal hematopoiesis, and the reduction of Tregs may be related to the pathogenesis of aplastic anemia. Meanwhile, Tregs could be looked as indicator to monitor the effectiveness of treatment.