发热型输液反应残留输液内毒素检查与原因分析

目的探讨患者输液过程中发生的发热型输液反应与输液内毒素限值的关系,为临床输液致发热型输液反应的原因分析提供输液内毒素限值的参考依据。方法依据2005年版《中国药典》（二部附录XI E细菌内毒素检查法）,建立了残留输液、留样输液、外购输液和加药输液的内毒素检查方法,并通过供试品阳性对照、阳性对照和阴性对照等实验验证了方法的可行性和结果的可靠性。结果我院两年来发生的发热型输液反应,剩余输液内毒素含量检查符合规定。结论检查分析认为,所发生的发热型输液反应应排除输液内毒素含量超标因素。反应的发生与患者对内毒素的敏感性,输液中的微粒数,输液速度等可能存在一定关系。

Bacterial endotoxin Iimited test of the residual infusion fluids and analysis of causes for fever-type infusion reaction

OBJECTIVE To explore the relation between the feverish reaction happened on the duration of infusion therapy and limitation value of bacterial endotoxin of the infusion,and provide an evidences of limitation value of the endotoxinin the infusion fluid for the causes analysis of fever-type infusion reaction.METHODS According to the Appendix of the Chinese Pharmacopoiea Ⅱ 2005,It has been founded that the test methods of endotoxin was established in residual fluids taking place fever reaction,the transfusion samples kepting in stock and purchasing from market, and transfusion added another therapeutic drugs. Furthermore, the feasibility of the method and the reliability of test results were being validated by the experiment of position control with and with- out samples, negative control trial. RESULTS It have been affirmed that the endotoxin content of residual infusion fluids are accord with standard qualification by the two years in our hospital. CONCLUSION The causes occurring feverish infusion reaction should be excluded from endotoxin infusion super-standard factors. The occurrance of feverish reaction were associated with the hypersensitivity of patients to endotoxin, insolvable particle number of infusion fluid, and infusion speed.